Here we use the inverse-rank normalized data - visually this is more
normally distributed.
Quantitative plaque traits
detach("package:EnsDb.Hsapiens.v86", unload = TRUE)
detach("package:ensembldb", unload = TRUE)
Analysis of continuous/quantitative plaque traits as a function of
plaque CONVOCALS_downstream expression levels.
library(dplyr)
library(MASS)
GLM.results <- data.frame(matrix(NA, ncol = 15, nrow = 0))
cat("Running linear regression...\n")
Running linear regression...
for (target_of_interest in 1:length(TRAITS.TARGET.RANK)) {
TARGET = TRAITS.TARGET.RANK[target_of_interest]
cat(paste0("\nAnalysis of ",TARGET,".\n"))
for (trait in 1:length(TRAITS.CON.RANK)) {
TRAIT = TRAITS.CON.RANK[trait]
cat(paste0("\n- processing ",TRAIT,"\n\n"))
currentDF <- as.data.frame(AERNASE.clin.targets %>%
dplyr::select(., TARGET, TRAIT, COVARIATES_M1) %>%
filter(complete.cases(.))) %>%
filter_if(~is.numeric(.), all_vars(!is.infinite(.)))
# # for debug
# print(DT::datatable(currentDF))
# print(nrow(currentDF))
# print(str(currentDF))
### univariate
# fit <- lm(currentDF[,TARGET] ~ currentDF[,TRAIT] + Age + Gender + ORdate_year, data = currentDF)
fit <- lm(currentDF[,TARGET] ~ currentDF[,TRAIT] + Age + Gender + ORdate_epoch, data = currentDF)
model_step <- stepAIC(fit, direction = "both", trace = FALSE)
# print(model_step)
# print(summary(fit))
GLM.results.TEMP <- data.frame(matrix(NA, ncol = 15, nrow = 0))
GLM.results.TEMP[1,] = GLM.CON(fit, "AERNASE.clin.targets", TARGET, TRAIT, verbose = TRUE)
GLM.results = rbind(GLM.results, GLM.results.TEMP)
}
}
Analysis of SCGB3A2.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SCGB3A2 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SCGB3A2
Trait/outcome.............: MAC_rankNorm
Effect size...............: 0.01799
Standard error............: 0.046054
Odds ratio (effect size)..: 1.018
Lower 95% CI..............: 0.93
Upper 95% CI..............: 1.114
T-value...................: 0.390622
P-value...................: 0.6961729
R^2.......................: 0.039519
Adjusted r^2..............: 0.035072
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SCGB3A2 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SCGB3A2
Trait/outcome.............: SMC_rankNorm
Effect size...............: 0.181628
Standard error............: 0.047409
Odds ratio (effect size)..: 1.199
Lower 95% CI..............: 1.093
Upper 95% CI..............: 1.316
T-value...................: 3.831131
P-value...................: 0.0001368094
R^2.......................: 0.055483
Adjusted r^2..............: 0.0511
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SCGB3A2 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SCGB3A2
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: -0.019043
Standard error............: 0.042244
Odds ratio (effect size)..: 0.981
Lower 95% CI..............: 0.903
Upper 95% CI..............: 1.066
T-value...................: -0.450789
P-value...................: 0.6522554
R^2.......................: 0.040038
Adjusted r^2..............: 0.035578
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SCGB3A2 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SCGB3A2
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: 0.005692
Standard error............: 0.046455
Odds ratio (effect size)..: 1.006
Lower 95% CI..............: 0.918
Upper 95% CI..............: 1.102
T-value...................: 0.122529
P-value...................: 0.9025104
R^2.......................: 0.037958
Adjusted r^2..............: 0.033189
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of LIX1.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LIX1 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LIX1
Trait/outcome.............: MAC_rankNorm
Effect size...............: -0.075852
Standard error............: 0.033596
Odds ratio (effect size)..: 0.927
Lower 95% CI..............: 0.868
Upper 95% CI..............: 0.99
T-value...................: -2.257813
P-value...................: 0.02420618
R^2.......................: 0.029326
Adjusted r^2..............: 0.024832
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LIX1 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LIX1
Trait/outcome.............: SMC_rankNorm
Effect size...............: 0.16833
Standard error............: 0.034404
Odds ratio (effect size)..: 1.183
Lower 95% CI..............: 1.106
Upper 95% CI..............: 1.266
T-value...................: 4.89278
P-value...................: 1.186341e-06
R^2.......................: 0.050067
Adjusted r^2..............: 0.045659
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LIX1 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LIX1
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: 0.033062
Standard error............: 0.030847
Odds ratio (effect size)..: 1.034
Lower 95% CI..............: 0.973
Upper 95% CI..............: 1.098
T-value...................: 1.071804
P-value...................: 0.2841082
R^2.......................: 0.024986
Adjusted r^2..............: 0.020457
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LIX1 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LIX1
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: 0.037287
Standard error............: 0.033548
Odds ratio (effect size)..: 1.038
Lower 95% CI..............: 0.972
Upper 95% CI..............: 1.109
T-value...................: 1.111449
P-value...................: 0.2667063
R^2.......................: 0.025747
Adjusted r^2..............: 0.020918
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of IGSF9B.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' IGSF9B ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: IGSF9B
Trait/outcome.............: MAC_rankNorm
Effect size...............: 0.045738
Standard error............: 0.045501
Odds ratio (effect size)..: 1.047
Lower 95% CI..............: 0.957
Upper 95% CI..............: 1.144
T-value...................: 1.005198
P-value...................: 0.315083
R^2.......................: 0.039292
Adjusted r^2..............: 0.034844
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' IGSF9B ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: IGSF9B
Trait/outcome.............: SMC_rankNorm
Effect size...............: 0.190025
Standard error............: 0.046829
Odds ratio (effect size)..: 1.209
Lower 95% CI..............: 1.103
Upper 95% CI..............: 1.326
T-value...................: 4.057814
P-value...................: 5.403206e-05
R^2.......................: 0.056203
Adjusted r^2..............: 0.051824
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' IGSF9B ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: IGSF9B
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: -0.029395
Standard error............: 0.041764
Odds ratio (effect size)..: 0.971
Lower 95% CI..............: 0.895
Upper 95% CI..............: 1.054
T-value...................: -0.703845
P-value...................: 0.4817195
R^2.......................: 0.039039
Adjusted r^2..............: 0.034575
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' IGSF9B ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: IGSF9B
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: -0.012322
Standard error............: 0.045543
Odds ratio (effect size)..: 0.988
Lower 95% CI..............: 0.903
Upper 95% CI..............: 1.08
T-value...................: -0.270551
P-value...................: 0.7868056
R^2.......................: 0.039382
Adjusted r^2..............: 0.034621
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of ALB.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ALB ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ALB
Trait/outcome.............: MAC_rankNorm
Effect size...............: -0.033195
Standard error............: 0.037057
Odds ratio (effect size)..: 0.967
Lower 95% CI..............: 0.9
Upper 95% CI..............: 1.04
T-value...................: -0.895779
P-value...................: 0.3706206
R^2.......................: 0.014282
Adjusted r^2..............: 0.009718
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ALB ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ALB
Trait/outcome.............: SMC_rankNorm
Effect size...............: 0.146313
Standard error............: 0.038167
Odds ratio (effect size)..: 1.158
Lower 95% CI..............: 1.074
Upper 95% CI..............: 1.247
T-value...................: 3.833487
P-value...................: 0.0001355271
R^2.......................: 0.03016
Adjusted r^2..............: 0.02566
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ALB ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ALB
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: -0.077312
Standard error............: 0.033866
Odds ratio (effect size)..: 0.926
Lower 95% CI..............: 0.866
Upper 95% CI..............: 0.989
T-value...................: -2.28291
P-value...................: 0.02267866
R^2.......................: 0.01991
Adjusted r^2..............: 0.015357
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ALB ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ALB
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: -0.039244
Standard error............: 0.037221
Odds ratio (effect size)..: 0.962
Lower 95% CI..............: 0.894
Upper 95% CI..............: 1.034
T-value...................: -1.054367
P-value...................: 0.2920303
R^2.......................: 0.020859
Adjusted r^2..............: 0.016005
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of OR10A4.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' OR10A4 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: OR10A4
Trait/outcome.............: MAC_rankNorm
Effect size...............: -0.040967
Standard error............: 0.039797
Odds ratio (effect size)..: 0.96
Lower 95% CI..............: 0.888
Upper 95% CI..............: 1.038
T-value...................: -1.029401
P-value...................: 0.3035793
R^2.......................: 0.008564
Adjusted r^2..............: 0.003974
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' OR10A4 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: OR10A4
Trait/outcome.............: SMC_rankNorm
Effect size...............: 0.154687
Standard error............: 0.040988
Odds ratio (effect size)..: 1.167
Lower 95% CI..............: 1.077
Upper 95% CI..............: 1.265
T-value...................: 3.773946
P-value...................: 0.0001716837
R^2.......................: 0.023586
Adjusted r^2..............: 0.019055
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' OR10A4 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: OR10A4
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: -0.093099
Standard error............: 0.036364
Odds ratio (effect size)..: 0.911
Lower 95% CI..............: 0.848
Upper 95% CI..............: 0.978
T-value...................: -2.560224
P-value...................: 0.01063007
R^2.......................: 0.015145
Adjusted r^2..............: 0.01057
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' OR10A4 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: OR10A4
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: -0.023302
Standard error............: 0.03988
Odds ratio (effect size)..: 0.977
Lower 95% CI..............: 0.904
Upper 95% CI..............: 1.056
T-value...................: -0.58429
P-value...................: 0.5591887
R^2.......................: 0.012449
Adjusted r^2..............: 0.007555
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of RASEF.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' RASEF ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: RASEF
Trait/outcome.............: MAC_rankNorm
Effect size...............: 0.04048
Standard error............: 0.03731
Odds ratio (effect size)..: 1.041
Lower 95% CI..............: 0.968
Upper 95% CI..............: 1.12
T-value...................: 1.084969
P-value...................: 0.278238
R^2.......................: 0.040674
Adjusted r^2..............: 0.036232
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' RASEF ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: RASEF
Trait/outcome.............: SMC_rankNorm
Effect size...............: 0.153066
Standard error............: 0.038348
Odds ratio (effect size)..: 1.165
Lower 95% CI..............: 1.081
Upper 95% CI..............: 1.256
T-value...................: 3.991539
P-value...................: 7.123374e-05
R^2.......................: 0.057533
Adjusted r^2..............: 0.05316
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' RASEF ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: RASEF
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: -0.006068
Standard error............: 0.0342
Odds ratio (effect size)..: 0.994
Lower 95% CI..............: 0.93
Upper 95% CI..............: 1.063
T-value...................: -0.177429
P-value...................: 0.8592134
R^2.......................: 0.040528
Adjusted r^2..............: 0.03607
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' RASEF ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: RASEF
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: -0.004509
Standard error............: 0.037707
Odds ratio (effect size)..: 0.996
Lower 95% CI..............: 0.925
Upper 95% CI..............: 1.072
T-value...................: -0.119591
P-value...................: 0.9048368
R^2.......................: 0.040129
Adjusted r^2..............: 0.035371
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of NEDD4.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' NEDD4 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: NEDD4
Trait/outcome.............: MAC_rankNorm
Effect size...............: 0.00625
Standard error............: 0.035705
Odds ratio (effect size)..: 1.006
Lower 95% CI..............: 0.938
Upper 95% CI..............: 1.079
T-value...................: 0.175057
P-value...................: 0.8610762
R^2.......................: 0.017462
Adjusted r^2..............: 0.012913
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' NEDD4 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: NEDD4
Trait/outcome.............: SMC_rankNorm
Effect size...............: 0.131234
Standard error............: 0.036794
Odds ratio (effect size)..: 1.14
Lower 95% CI..............: 1.061
Upper 95% CI..............: 1.226
T-value...................: 3.566748
P-value...................: 0.0003813519
R^2.......................: 0.032149
Adjusted r^2..............: 0.027658
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' NEDD4 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: NEDD4
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: -0.050527
Standard error............: 0.032669
Odds ratio (effect size)..: 0.951
Lower 95% CI..............: 0.892
Upper 95% CI..............: 1.014
T-value...................: -1.546633
P-value...................: 0.1223191
R^2.......................: 0.020932
Adjusted r^2..............: 0.016384
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' NEDD4 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: NEDD4
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: -0.009867
Standard error............: 0.036018
Odds ratio (effect size)..: 0.99
Lower 95% CI..............: 0.923
Upper 95% CI..............: 1.063
T-value...................: -0.273952
P-value...................: 0.7841918
R^2.......................: 0.020621
Adjusted r^2..............: 0.015766
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of TCL1A.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TCL1A ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TCL1A
Trait/outcome.............: MAC_rankNorm
Effect size...............: -0.09169
Standard error............: 0.030882
Odds ratio (effect size)..: 0.912
Lower 95% CI..............: 0.859
Upper 95% CI..............: 0.969
T-value...................: -2.969013
P-value...................: 0.003070145
R^2.......................: 0.045376
Adjusted r^2..............: 0.040957
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TCL1A ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TCL1A
Trait/outcome.............: SMC_rankNorm
Effect size...............: 0.135419
Standard error............: 0.031839
Odds ratio (effect size)..: 1.145
Lower 95% CI..............: 1.076
Upper 95% CI..............: 1.219
T-value...................: 4.25328
P-value...................: 2.337017e-05
R^2.......................: 0.056027
Adjusted r^2..............: 0.051646
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TCL1A ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TCL1A
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: 0.035532
Standard error............: 0.028441
Odds ratio (effect size)..: 1.036
Lower 95% CI..............: 0.98
Upper 95% CI..............: 1.096
T-value...................: 1.24932
P-value...................: 0.2118875
R^2.......................: 0.037962
Adjusted r^2..............: 0.033493
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TCL1A ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TCL1A
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: 0.037622
Standard error............: 0.030912
Odds ratio (effect size)..: 1.038
Lower 95% CI..............: 0.977
Upper 95% CI..............: 1.103
T-value...................: 1.217089
P-value...................: 0.2239261
R^2.......................: 0.038145
Adjusted r^2..............: 0.033378
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of FBXO15.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FBXO15 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FBXO15
Trait/outcome.............: MAC_rankNorm
Effect size...............: -0.025578
Standard error............: 0.035822
Odds ratio (effect size)..: 0.975
Lower 95% CI..............: 0.909
Upper 95% CI..............: 1.046
T-value...................: -0.714033
P-value...................: 0.4753994
R^2.......................: 0.014739
Adjusted r^2..............: 0.010177
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FBXO15 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FBXO15
Trait/outcome.............: SMC_rankNorm
Effect size...............: 0.139332
Standard error............: 0.036893
Odds ratio (effect size)..: 1.15
Lower 95% CI..............: 1.069
Upper 95% CI..............: 1.236
T-value...................: 3.776686
P-value...................: 0.0001698369
R^2.......................: 0.030284
Adjusted r^2..............: 0.025784
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FBXO15 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FBXO15
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: -0.042601
Standard error............: 0.032817
Odds ratio (effect size)..: 0.958
Lower 95% CI..............: 0.899
Upper 95% CI..............: 1.022
T-value...................: -1.298163
P-value...................: 0.1945789
R^2.......................: 0.016507
Adjusted r^2..............: 0.011938
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FBXO15 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FBXO15
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: -0.017621
Standard error............: 0.035978
Odds ratio (effect size)..: 0.983
Lower 95% CI..............: 0.916
Upper 95% CI..............: 1.054
T-value...................: -0.489774
P-value...................: 0.6244272
R^2.......................: 0.01844
Adjusted r^2..............: 0.013575
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of F5.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' F5 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: F5
Trait/outcome.............: MAC_rankNorm
Effect size...............: -0.020515
Standard error............: 0.035478
Odds ratio (effect size)..: 0.98
Lower 95% CI..............: 0.914
Upper 95% CI..............: 1.05
T-value...................: -0.57825
P-value...................: 0.5632461
R^2.......................: 0.018894
Adjusted r^2..............: 0.014352
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' F5 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: F5
Trait/outcome.............: SMC_rankNorm
Effect size...............: 0.161335
Standard error............: 0.036458
Odds ratio (effect size)..: 1.175
Lower 95% CI..............: 1.094
Upper 95% CI..............: 1.262
T-value...................: 4.425201
P-value...................: 1.087008e-05
R^2.......................: 0.040593
Adjusted r^2..............: 0.036141
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' F5 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: F5
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: -0.043202
Standard error............: 0.032508
Odds ratio (effect size)..: 0.958
Lower 95% CI..............: 0.899
Upper 95% CI..............: 1.021
T-value...................: -1.328957
P-value...................: 0.1842141
R^2.......................: 0.021207
Adjusted r^2..............: 0.01666
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' F5 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: F5
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: -0.011728
Standard error............: 0.035864
Odds ratio (effect size)..: 0.988
Lower 95% CI..............: 0.921
Upper 95% CI..............: 1.06
T-value...................: -0.327006
P-value...................: 0.7437484
R^2.......................: 0.021638
Adjusted r^2..............: 0.016789
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of TMEM212.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TMEM212 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TMEM212
Trait/outcome.............: MAC_rankNorm
Effect size...............: -0.018474
Standard error............: 0.034356
Odds ratio (effect size)..: 0.982
Lower 95% CI..............: 0.918
Upper 95% CI..............: 1.05
T-value...................: -0.537715
P-value...................: 0.5909122
R^2.......................: 0.014889
Adjusted r^2..............: 0.010328
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TMEM212 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TMEM212
Trait/outcome.............: SMC_rankNorm
Effect size...............: 0.166111
Standard error............: 0.03522
Odds ratio (effect size)..: 1.181
Lower 95% CI..............: 1.102
Upper 95% CI..............: 1.265
T-value...................: 4.716422
P-value...................: 2.798836e-06
R^2.......................: 0.039578
Adjusted r^2..............: 0.035121
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TMEM212 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TMEM212
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: -0.067831
Standard error............: 0.031405
Odds ratio (effect size)..: 0.934
Lower 95% CI..............: 0.879
Upper 95% CI..............: 0.994
T-value...................: -2.1599
P-value...................: 0.03105584
R^2.......................: 0.020433
Adjusted r^2..............: 0.015882
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TMEM212 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TMEM212
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: -0.026741
Standard error............: 0.034505
Odds ratio (effect size)..: 0.974
Lower 95% CI..............: 0.91
Upper 95% CI..............: 1.042
T-value...................: -0.775006
P-value...................: 0.438563
R^2.......................: 0.01972
Adjusted r^2..............: 0.014861
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of PTPRD.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' PTPRD ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: PTPRD
Trait/outcome.............: MAC_rankNorm
Effect size...............: -0.01693
Standard error............: 0.020546
Odds ratio (effect size)..: 0.983
Lower 95% CI..............: 0.944
Upper 95% CI..............: 1.024
T-value...................: -0.824006
P-value...................: 0.4101637
R^2.......................: 0.003574
Adjusted r^2..............: -0.001039
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' PTPRD ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: PTPRD
Trait/outcome.............: SMC_rankNorm
Effect size...............: 0.024803
Standard error............: 0.021258
Odds ratio (effect size)..: 1.025
Lower 95% CI..............: 0.983
Upper 95% CI..............: 1.069
T-value...................: 1.166724
P-value...................: 0.2436446
R^2.......................: 0.00481
Adjusted r^2..............: 0.000192
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' PTPRD ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: PTPRD
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: -0.021921
Standard error............: 0.01881
Odds ratio (effect size)..: 0.978
Lower 95% CI..............: 0.943
Upper 95% CI..............: 1.015
T-value...................: -1.165414
P-value...................: 0.2441741
R^2.......................: 0.004786
Adjusted r^2..............: 0.000163
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' PTPRD ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: PTPRD
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: -0.03714
Standard error............: 0.020427
Odds ratio (effect size)..: 0.964
Lower 95% CI..............: 0.926
Upper 95% CI..............: 1.003
T-value...................: -1.818206
P-value...................: 0.06940321
R^2.......................: 0.009951
Adjusted r^2..............: 0.005044
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of CYP46A1.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CYP46A1 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CYP46A1
Trait/outcome.............: MAC_rankNorm
Effect size...............: -0.021514
Standard error............: 0.035752
Odds ratio (effect size)..: 0.979
Lower 95% CI..............: 0.912
Upper 95% CI..............: 1.05
T-value...................: -0.601757
P-value...................: 0.5474935
R^2.......................: 0.00976
Adjusted r^2..............: 0.005175
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CYP46A1 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CYP46A1
Trait/outcome.............: SMC_rankNorm
Effect size...............: 0.142245
Standard error............: 0.036797
Odds ratio (effect size)..: 1.153
Lower 95% CI..............: 1.073
Upper 95% CI..............: 1.239
T-value...................: 3.865623
P-value...................: 0.0001191293
R^2.......................: 0.026087
Adjusted r^2..............: 0.021567
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CYP46A1 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CYP46A1
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: -0.062831
Standard error............: 0.03272
Odds ratio (effect size)..: 0.939
Lower 95% CI..............: 0.881
Upper 95% CI..............: 1.001
T-value...................: -1.920252
P-value...................: 0.05515617
R^2.......................: 0.013683
Adjusted r^2..............: 0.0091
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CYP46A1 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CYP46A1
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: -0.019511
Standard error............: 0.035917
Odds ratio (effect size)..: 0.981
Lower 95% CI..............: 0.914
Upper 95% CI..............: 1.052
T-value...................: -0.543222
P-value...................: 0.5871268
R^2.......................: 0.013909
Adjusted r^2..............: 0.009022
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of OR2T33.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' OR2T33 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: OR2T33
Trait/outcome.............: MAC_rankNorm
Effect size...............: 0.009338
Standard error............: 0.036839
Odds ratio (effect size)..: 1.009
Lower 95% CI..............: 0.939
Upper 95% CI..............: 1.085
T-value...................: 0.253486
P-value...................: 0.7999533
R^2.......................: 0.016579
Adjusted r^2..............: 0.012026
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' OR2T33 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: OR2T33
Trait/outcome.............: SMC_rankNorm
Effect size...............: 0.139074
Standard error............: 0.037921
Odds ratio (effect size)..: 1.149
Lower 95% CI..............: 1.067
Upper 95% CI..............: 1.238
T-value...................: 3.667506
P-value...................: 0.0002599413
R^2.......................: 0.031905
Adjusted r^2..............: 0.027413
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' OR2T33 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: OR2T33
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: -0.063112
Standard error............: 0.033688
Odds ratio (effect size)..: 0.939
Lower 95% CI..............: 0.879
Upper 95% CI..............: 1.003
T-value...................: -1.873438
P-value...................: 0.06134649
R^2.......................: 0.021041
Adjusted r^2..............: 0.016493
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' OR2T33 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: OR2T33
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: -0.024126
Standard error............: 0.037102
Odds ratio (effect size)..: 0.976
Lower 95% CI..............: 0.908
Upper 95% CI..............: 1.05
T-value...................: -0.650262
P-value...................: 0.5157083
R^2.......................: 0.0197
Adjusted r^2..............: 0.014841
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of SORBS2.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SORBS2 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SORBS2
Trait/outcome.............: MAC_rankNorm
Effect size...............: -0.091982
Standard error............: 0.038024
Odds ratio (effect size)..: 0.912
Lower 95% CI..............: 0.847
Upper 95% CI..............: 0.983
T-value...................: -2.419052
P-value...................: 0.01576667
R^2.......................: 0.018507
Adjusted r^2..............: 0.013963
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SORBS2 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SORBS2
Trait/outcome.............: SMC_rankNorm
Effect size...............: 0.088333
Standard error............: 0.039342
Odds ratio (effect size)..: 1.092
Lower 95% CI..............: 1.011
Upper 95% CI..............: 1.18
T-value...................: 2.245292
P-value...................: 0.02500215
R^2.......................: 0.016908
Adjusted r^2..............: 0.012346
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SORBS2 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SORBS2
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: -0.058604
Standard error............: 0.034862
Odds ratio (effect size)..: 0.943
Lower 95% CI..............: 0.881
Upper 95% CI..............: 1.01
T-value...................: -1.681048
P-value...................: 0.09311619
R^2.......................: 0.014381
Adjusted r^2..............: 0.009802
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SORBS2 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SORBS2
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: -0.052415
Standard error............: 0.037867
Odds ratio (effect size)..: 0.949
Lower 95% CI..............: 0.881
Upper 95% CI..............: 1.022
T-value...................: -1.384179
P-value...................: 0.1666862
R^2.......................: 0.016551
Adjusted r^2..............: 0.011677
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of ITGA7.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ITGA7 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ITGA7
Trait/outcome.............: MAC_rankNorm
Effect size...............: -0.027272
Standard error............: 0.031921
Odds ratio (effect size)..: 0.973
Lower 95% CI..............: 0.914
Upper 95% CI..............: 1.036
T-value...................: -0.854357
P-value...................: 0.3931442
R^2.......................: 0.018409
Adjusted r^2..............: 0.013865
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ITGA7 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ITGA7
Trait/outcome.............: SMC_rankNorm
Effect size...............: 0.108877
Standard error............: 0.032972
Odds ratio (effect size)..: 1.115
Lower 95% CI..............: 1.045
Upper 95% CI..............: 1.189
T-value...................: 3.302145
P-value...................: 0.0009989609
R^2.......................: 0.030189
Adjusted r^2..............: 0.025689
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ITGA7 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ITGA7
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: -0.064115
Standard error............: 0.029178
Odds ratio (effect size)..: 0.938
Lower 95% CI..............: 0.886
Upper 95% CI..............: 0.993
T-value...................: -2.19739
P-value...................: 0.02825826
R^2.......................: 0.023828
Adjusted r^2..............: 0.019293
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ITGA7 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ITGA7
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: -0.019798
Standard error............: 0.031959
Odds ratio (effect size)..: 0.98
Lower 95% CI..............: 0.921
Upper 95% CI..............: 1.044
T-value...................: -0.619466
P-value...................: 0.5357842
R^2.......................: 0.022349
Adjusted r^2..............: 0.017504
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of FOS.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FOS ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FOS
Trait/outcome.............: MAC_rankNorm
Effect size...............: -0.022198
Standard error............: 0.061957
Odds ratio (effect size)..: 0.978
Lower 95% CI..............: 0.866
Upper 95% CI..............: 1.104
T-value...................: -0.358273
P-value...................: 0.7202266
R^2.......................: 0.003983
Adjusted r^2..............: -0.000628
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FOS ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FOS
Trait/outcome.............: SMC_rankNorm
Effect size...............: -0.224372
Standard error............: 0.063739
Odds ratio (effect size)..: 0.799
Lower 95% CI..............: 0.705
Upper 95% CI..............: 0.905
T-value...................: -3.520195
P-value...................: 0.0004538281
R^2.......................: 0.017874
Adjusted r^2..............: 0.013316
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FOS ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FOS
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: 0.035898
Standard error............: 0.0568
Odds ratio (effect size)..: 1.037
Lower 95% CI..............: 0.927
Upper 95% CI..............: 1.159
T-value...................: 0.632009
P-value...................: 0.5275487
R^2.......................: 0.004211
Adjusted r^2..............: -0.000415
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FOS ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FOS
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: 0.031493
Standard error............: 0.061581
Odds ratio (effect size)..: 1.032
Lower 95% CI..............: 0.915
Upper 95% CI..............: 1.164
T-value...................: 0.511398
P-value...................: 0.6092124
R^2.......................: 0.006366
Adjusted r^2..............: 0.001441
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of HMOX1.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' HMOX1 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: HMOX1
Trait/outcome.............: MAC_rankNorm
Effect size...............: 0.0516
Standard error............: 0.039919
Odds ratio (effect size)..: 1.053
Lower 95% CI..............: 0.974
Upper 95% CI..............: 1.139
T-value...................: 1.292619
P-value...................: 0.1964885
R^2.......................: 0.010587
Adjusted r^2..............: 0.006006
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' HMOX1 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: HMOX1
Trait/outcome.............: SMC_rankNorm
Effect size...............: -0.177408
Standard error............: 0.040983
Odds ratio (effect size)..: 0.837
Lower 95% CI..............: 0.773
Upper 95% CI..............: 0.907
T-value...................: -4.328848
P-value...................: 1.674779e-05
R^2.......................: 0.029393
Adjusted r^2..............: 0.024889
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' HMOX1 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: HMOX1
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: 0.034321
Standard error............: 0.036601
Odds ratio (effect size)..: 1.035
Lower 95% CI..............: 0.963
Upper 95% CI..............: 1.112
T-value...................: 0.937689
P-value...................: 0.3486674
R^2.......................: 0.009505
Adjusted r^2..............: 0.004904
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' HMOX1 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: HMOX1
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: 0.054092
Standard error............: 0.039339
Odds ratio (effect size)..: 1.056
Lower 95% CI..............: 0.977
Upper 95% CI..............: 1.14
T-value...................: 1.375038
P-value...................: 0.1695013
R^2.......................: 0.011117
Adjusted r^2..............: 0.006216
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of LAPTM5.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LAPTM5 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LAPTM5
Trait/outcome.............: MAC_rankNorm
Effect size...............: 0.039785
Standard error............: 0.079616
Odds ratio (effect size)..: 1.041
Lower 95% CI..............: 0.89
Upper 95% CI..............: 1.216
T-value...................: 0.499714
P-value...................: 0.617404
R^2.......................: 0.003634
Adjusted r^2..............: -0.000979
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LAPTM5 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LAPTM5
Trait/outcome.............: SMC_rankNorm
Effect size...............: -0.358584
Standard error............: 0.0816
Odds ratio (effect size)..: 0.699
Lower 95% CI..............: 0.595
Upper 95% CI..............: 0.82
T-value...................: -4.394417
P-value...................: 1.249111e-05
R^2.......................: 0.025013
Adjusted r^2..............: 0.020489
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LAPTM5 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LAPTM5
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: 0.11374
Standard error............: 0.072837
Odds ratio (effect size)..: 1.12
Lower 95% CI..............: 0.971
Upper 95% CI..............: 1.292
T-value...................: 1.561574
P-value...................: 0.1187559
R^2.......................: 0.006139
Adjusted r^2..............: 0.001522
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LAPTM5 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LAPTM5
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: 0.034489
Standard error............: 0.078925
Odds ratio (effect size)..: 1.035
Lower 95% CI..............: 0.887
Upper 95% CI..............: 1.208
T-value...................: 0.436991
P-value...................: 0.6622347
R^2.......................: 0.006782
Adjusted r^2..............: 0.001859
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of MMP9.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' MMP9 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: MMP9
Trait/outcome.............: MAC_rankNorm
Effect size...............: 0.075837
Standard error............: 0.074739
Odds ratio (effect size)..: 1.079
Lower 95% CI..............: 0.932
Upper 95% CI..............: 1.249
T-value...................: 1.014691
P-value...................: 0.310537
R^2.......................: 0.003889
Adjusted r^2..............: -0.000722
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' MMP9 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: MMP9
Trait/outcome.............: SMC_rankNorm
Effect size...............: -0.373842
Standard error............: 0.076439
Odds ratio (effect size)..: 0.688
Lower 95% CI..............: 0.592
Upper 95% CI..............: 0.799
T-value...................: -4.89072
P-value...................: 1.198486e-06
R^2.......................: 0.029517
Adjusted r^2..............: 0.025014
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' MMP9 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: MMP9
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: 0.107832
Standard error............: 0.068426
Odds ratio (effect size)..: 1.114
Lower 95% CI..............: 0.974
Upper 95% CI..............: 1.274
T-value...................: 1.575877
P-value...................: 0.1154215
R^2.......................: 0.00554
Adjusted r^2..............: 0.00092
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' MMP9 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: MMP9
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: 0.063855
Standard error............: 0.074587
Odds ratio (effect size)..: 1.066
Lower 95% CI..............: 0.921
Upper 95% CI..............: 1.234
T-value...................: 0.856124
P-value...................: 0.3921835
R^2.......................: 0.00292
Adjusted r^2..............: -0.002023
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of SIGLEC1.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SIGLEC1 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SIGLEC1
Trait/outcome.............: MAC_rankNorm
Effect size...............: 0.038867
Standard error............: 0.067744
Odds ratio (effect size)..: 1.04
Lower 95% CI..............: 0.91
Upper 95% CI..............: 1.187
T-value...................: 0.573738
P-value...................: 0.5662943
R^2.......................: 0.005706
Adjusted r^2..............: 0.001103
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SIGLEC1 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SIGLEC1
Trait/outcome.............: SMC_rankNorm
Effect size...............: -0.278898
Standard error............: 0.069565
Odds ratio (effect size)..: 0.757
Lower 95% CI..............: 0.66
Upper 95% CI..............: 0.867
T-value...................: -4.009182
P-value...................: 6.620613e-05
R^2.......................: 0.023132
Adjusted r^2..............: 0.018599
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SIGLEC1 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SIGLEC1
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: 0.095751
Standard error............: 0.06199
Odds ratio (effect size)..: 1.1
Lower 95% CI..............: 0.975
Upper 95% CI..............: 1.243
T-value...................: 1.544625
P-value...................: 0.1228044
R^2.......................: 0.007836
Adjusted r^2..............: 0.003227
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SIGLEC1 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SIGLEC1
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: 0.017386
Standard error............: 0.067424
Odds ratio (effect size)..: 1.018
Lower 95% CI..............: 0.892
Upper 95% CI..............: 1.161
T-value...................: 0.257869
P-value...................: 0.7965741
R^2.......................: 0.007413
Adjusted r^2..............: 0.002493
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of FTL.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FTL ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FTL
Trait/outcome.............: MAC_rankNorm
Effect size...............: 0.017409
Standard error............: 0.079927
Odds ratio (effect size)..: 1.018
Lower 95% CI..............: 0.87
Upper 95% CI..............: 1.19
T-value...................: 0.217808
P-value...................: 0.8276302
R^2.......................: 0.002577
Adjusted r^2..............: -0.002041
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FTL ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FTL
Trait/outcome.............: SMC_rankNorm
Effect size...............: -0.317465
Standard error............: 0.082082
Odds ratio (effect size)..: 0.728
Lower 95% CI..............: 0.62
Upper 95% CI..............: 0.855
T-value...................: -3.867642
P-value...................: 0.0001181644
R^2.......................: 0.019356
Adjusted r^2..............: 0.014805
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FTL ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FTL
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: 0.045428
Standard error............: 0.073213
Odds ratio (effect size)..: 1.046
Lower 95% CI..............: 0.907
Upper 95% CI..............: 1.208
T-value...................: 0.620485
P-value...................: 0.535103
R^2.......................: 0.002886
Adjusted r^2..............: -0.001746
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FTL ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FTL
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: 0.021477
Standard error............: 0.078965
Odds ratio (effect size)..: 1.022
Lower 95% CI..............: 0.875
Upper 95% CI..............: 1.193
T-value...................: 0.271985
P-value...................: 0.7857029
R^2.......................: 0.004713
Adjusted r^2..............: -0.000221
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of CD14.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CD14 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CD14
Trait/outcome.............: MAC_rankNorm
Effect size...............: 0.045545
Standard error............: 0.078061
Odds ratio (effect size)..: 1.047
Lower 95% CI..............: 0.898
Upper 95% CI..............: 1.22
T-value...................: 0.583449
P-value...................: 0.5597432
R^2.......................: 0.005132
Adjusted r^2..............: 0.000526
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CD14 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CD14
Trait/outcome.............: SMC_rankNorm
Effect size...............: -0.29738
Standard error............: 0.080274
Odds ratio (effect size)..: 0.743
Lower 95% CI..............: 0.635
Upper 95% CI..............: 0.869
T-value...................: -3.704578
P-value...................: 0.0002252345
R^2.......................: 0.020061
Adjusted r^2..............: 0.015513
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CD14 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CD14
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: 0.066899
Standard error............: 0.0715
Odds ratio (effect size)..: 1.069
Lower 95% CI..............: 0.929
Upper 95% CI..............: 1.23
T-value...................: 0.935647
P-value...................: 0.3497175
R^2.......................: 0.005661
Adjusted r^2..............: 0.001041
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CD14 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CD14
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: 0.02019
Standard error............: 0.077651
Odds ratio (effect size)..: 1.02
Lower 95% CI..............: 0.876
Upper 95% CI..............: 1.188
T-value...................: 0.26001
P-value...................: 0.7949226
R^2.......................: 0.007596
Adjusted r^2..............: 0.002677
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of HCST.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' HCST ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: HCST
Trait/outcome.............: MAC_rankNorm
Effect size...............: 0.035916
Standard error............: 0.077071
Odds ratio (effect size)..: 1.037
Lower 95% CI..............: 0.891
Upper 95% CI..............: 1.206
T-value...................: 0.466018
P-value...................: 0.6413197
R^2.......................: 0.005482
Adjusted r^2..............: 0.000878
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' HCST ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: HCST
Trait/outcome.............: SMC_rankNorm
Effect size...............: -0.290021
Standard error............: 0.079316
Odds ratio (effect size)..: 0.748
Lower 95% CI..............: 0.641
Upper 95% CI..............: 0.874
T-value...................: -3.656518
P-value...................: 0.0002711566
R^2.......................: 0.019982
Adjusted r^2..............: 0.015434
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' HCST ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: HCST
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: 0.09001
Standard error............: 0.070542
Odds ratio (effect size)..: 1.094
Lower 95% CI..............: 0.953
Upper 95% CI..............: 1.256
T-value...................: 1.275971
P-value...................: 0.2023098
R^2.......................: 0.006909
Adjusted r^2..............: 0.002295
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' HCST ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: HCST
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: 0.038898
Standard error............: 0.076466
Odds ratio (effect size)..: 1.04
Lower 95% CI..............: 0.895
Upper 95% CI..............: 1.208
T-value...................: 0.508695
P-value...................: 0.6111051
R^2.......................: 0.010011
Adjusted r^2..............: 0.005103
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of TIMP3.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TIMP3 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TIMP3
Trait/outcome.............: MAC_rankNorm
Effect size...............: 0.059325
Standard error............: 0.067665
Odds ratio (effect size)..: 1.061
Lower 95% CI..............: 0.929
Upper 95% CI..............: 1.212
T-value...................: 0.876739
P-value...................: 0.380872
R^2.......................: 0.010615
Adjusted r^2..............: 0.006035
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TIMP3 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TIMP3
Trait/outcome.............: SMC_rankNorm
Effect size...............: -0.18139
Standard error............: 0.069842
Odds ratio (effect size)..: 0.834
Lower 95% CI..............: 0.727
Upper 95% CI..............: 0.956
T-value...................: -2.59714
P-value...................: 0.009560593
R^2.......................: 0.017046
Adjusted r^2..............: 0.012485
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TIMP3 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TIMP3
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: -0.029893
Standard error............: 0.062044
Odds ratio (effect size)..: 0.971
Lower 95% CI..............: 0.859
Upper 95% CI..............: 1.096
T-value...................: -0.481812
P-value...................: 0.6300619
R^2.......................: 0.009624
Adjusted r^2..............: 0.005022
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TIMP3 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TIMP3
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: -0.025315
Standard error............: 0.067455
Odds ratio (effect size)..: 0.975
Lower 95% CI..............: 0.854
Upper 95% CI..............: 1.113
T-value...................: -0.375294
P-value...................: 0.7075402
R^2.......................: 0.010592
Adjusted r^2..............: 0.005688
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of CCL2.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CCL2 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CCL2
Trait/outcome.............: MAC_rankNorm
Effect size...............: -0.044765
Standard error............: 0.064119
Odds ratio (effect size)..: 0.956
Lower 95% CI..............: 0.843
Upper 95% CI..............: 1.084
T-value...................: -0.698156
P-value...................: 0.4852674
R^2.......................: 0.006252
Adjusted r^2..............: 0.001652
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CCL2 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CCL2
Trait/outcome.............: SMC_rankNorm
Effect size...............: -0.250689
Standard error............: 0.065902
Odds ratio (effect size)..: 0.778
Lower 95% CI..............: 0.684
Upper 95% CI..............: 0.886
T-value...................: -3.803974
P-value...................: 0.0001524425
R^2.......................: 0.022027
Adjusted r^2..............: 0.017489
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CCL2 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CCL2
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: 0.002588
Standard error............: 0.058802
Odds ratio (effect size)..: 1.003
Lower 95% CI..............: 0.893
Upper 95% CI..............: 1.125
T-value...................: 0.044013
P-value...................: 0.9649039
R^2.......................: 0.00567
Adjusted r^2..............: 0.001051
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CCL2 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CCL2
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: 0.024892
Standard error............: 0.063558
Odds ratio (effect size)..: 1.025
Lower 95% CI..............: 0.905
Upper 95% CI..............: 1.161
T-value...................: 0.391646
P-value...................: 0.6954231
R^2.......................: 0.008408
Adjusted r^2..............: 0.003494
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of SAT1.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SAT1 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SAT1
Trait/outcome.............: MAC_rankNorm
Effect size...............: 0.00292
Standard error............: 0.076252
Odds ratio (effect size)..: 1.003
Lower 95% CI..............: 0.864
Upper 95% CI..............: 1.165
T-value...................: 0.038298
P-value...................: 0.9694591
R^2.......................: 0.00453
Adjusted r^2..............: -7.8e-05
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SAT1 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SAT1
Trait/outcome.............: SMC_rankNorm
Effect size...............: -0.330388
Standard error............: 0.078139
Odds ratio (effect size)..: 0.719
Lower 95% CI..............: 0.617
Upper 95% CI..............: 0.838
T-value...................: -4.228208
P-value...................: 2.607247e-05
R^2.......................: 0.024558
Adjusted r^2..............: 0.020032
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SAT1 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SAT1
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: 0.026399
Standard error............: 0.069821
Odds ratio (effect size)..: 1.027
Lower 95% CI..............: 0.895
Upper 95% CI..............: 1.177
T-value...................: 0.378096
P-value...................: 0.7054521
R^2.......................: 0.004634
Adjusted r^2..............: 9e-06
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SAT1 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SAT1
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: 0.021537
Standard error............: 0.075705
Odds ratio (effect size)..: 1.022
Lower 95% CI..............: 0.881
Upper 95% CI..............: 1.185
T-value...................: 0.284489
P-value...................: 0.7761083
R^2.......................: 0.006378
Adjusted r^2..............: 0.001453
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of CD163.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CD163 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CD163
Trait/outcome.............: MAC_rankNorm
Effect size...............: 0.00116
Standard error............: 0.049738
Odds ratio (effect size)..: 1.001
Lower 95% CI..............: 0.908
Upper 95% CI..............: 1.104
T-value...................: 0.02332
P-value...................: 0.9814008
R^2.......................: 0.002808
Adjusted r^2..............: -0.001809
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CD163 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CD163
Trait/outcome.............: SMC_rankNorm
Effect size...............: -0.193213
Standard error............: 0.05114
Odds ratio (effect size)..: 0.824
Lower 95% CI..............: 0.746
Upper 95% CI..............: 0.911
T-value...................: -3.778142
P-value...................: 0.0001688635
R^2.......................: 0.018994
Adjusted r^2..............: 0.014442
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CD163 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CD163
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: 0.016507
Standard error............: 0.045602
Odds ratio (effect size)..: 1.017
Lower 95% CI..............: 0.93
Upper 95% CI..............: 1.112
T-value...................: 0.361991
P-value...................: 0.7174474
R^2.......................: 0.003004
Adjusted r^2..............: -0.001628
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CD163 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CD163
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: 0.020021
Standard error............: 0.04938
Odds ratio (effect size)..: 1.02
Lower 95% CI..............: 0.926
Upper 95% CI..............: 1.124
T-value...................: 0.405446
P-value...................: 0.6852572
R^2.......................: 0.003732
Adjusted r^2..............: -0.001206
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of PTGDS.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' PTGDS ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: PTGDS
Trait/outcome.............: MAC_rankNorm
Effect size...............: 0.07203
Standard error............: 0.058021
Odds ratio (effect size)..: 1.075
Lower 95% CI..............: 0.959
Upper 95% CI..............: 1.204
T-value...................: 1.241435
P-value...................: 0.2147821
R^2.......................: 0.005419
Adjusted r^2..............: 0.000815
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' PTGDS ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: PTGDS
Trait/outcome.............: SMC_rankNorm
Effect size...............: -0.154708
Standard error............: 0.059964
Odds ratio (effect size)..: 0.857
Lower 95% CI..............: 0.762
Upper 95% CI..............: 0.964
T-value...................: -2.580002
P-value...................: 0.01004443
R^2.......................: 0.011181
Adjusted r^2..............: 0.006592
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' PTGDS ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: PTGDS
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: 0.00745
Standard error............: 0.053258
Odds ratio (effect size)..: 1.007
Lower 95% CI..............: 0.908
Upper 95% CI..............: 1.118
T-value...................: 0.139886
P-value...................: 0.8887831
R^2.......................: 0.003636
Adjusted r^2..............: -0.000992
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' PTGDS ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: PTGDS
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: 0.076181
Standard error............: 0.058227
Odds ratio (effect size)..: 1.079
Lower 95% CI..............: 0.963
Upper 95% CI..............: 1.21
T-value...................: 1.308344
P-value...................: 0.1911292
R^2.......................: 0.007067
Adjusted r^2..............: 0.002145
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of LGALS9.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LGALS9 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LGALS9
Trait/outcome.............: MAC_rankNorm
Effect size...............: 0.036416
Standard error............: 0.064227
Odds ratio (effect size)..: 1.037
Lower 95% CI..............: 0.914
Upper 95% CI..............: 1.176
T-value...................: 0.566985
P-value...................: 0.5708718
R^2.......................: 0.004688
Adjusted r^2..............: 8e-05
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LGALS9 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LGALS9
Trait/outcome.............: SMC_rankNorm
Effect size...............: -0.255799
Standard error............: 0.065956
Odds ratio (effect size)..: 0.774
Lower 95% CI..............: 0.68
Upper 95% CI..............: 0.881
T-value...................: -3.878321
P-value...................: 0.000113182
R^2.......................: 0.021057
Adjusted r^2..............: 0.016515
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LGALS9 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LGALS9
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: 0.054661
Standard error............: 0.058801
Odds ratio (effect size)..: 1.056
Lower 95% CI..............: 0.941
Upper 95% CI..............: 1.185
T-value...................: 0.929602
P-value...................: 0.352838
R^2.......................: 0.005129
Adjusted r^2..............: 0.000507
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LGALS9 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LGALS9
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: 0.047972
Standard error............: 0.063624
Odds ratio (effect size)..: 1.049
Lower 95% CI..............: 0.926
Upper 95% CI..............: 1.188
T-value...................: 0.753995
P-value...................: 0.451072
R^2.......................: 0.008663
Adjusted r^2..............: 0.003749
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of ACKR1.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ACKR1 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ACKR1
Trait/outcome.............: MAC_rankNorm
Effect size...............: 0.033286
Standard error............: 0.053746
Odds ratio (effect size)..: 1.034
Lower 95% CI..............: 0.93
Upper 95% CI..............: 1.149
T-value...................: 0.619333
P-value...................: 0.5358605
R^2.......................: 0.007231
Adjusted r^2..............: 0.002635
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ACKR1 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ACKR1
Trait/outcome.............: SMC_rankNorm
Effect size...............: -0.200006
Standard error............: 0.055312
Odds ratio (effect size)..: 0.819
Lower 95% CI..............: 0.735
Upper 95% CI..............: 0.912
T-value...................: -3.616001
P-value...................: 0.0003165611
R^2.......................: 0.021395
Adjusted r^2..............: 0.016854
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ACKR1 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ACKR1
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: 0.001823
Standard error............: 0.049311
Odds ratio (effect size)..: 1.002
Lower 95% CI..............: 0.91
Upper 95% CI..............: 1.103
T-value...................: 0.036969
P-value...................: 0.9705185
R^2.......................: 0.006634
Adjusted r^2..............: 0.002019
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ACKR1 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ACKR1
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: 0.10824
Standard error............: 0.05401
Odds ratio (effect size)..: 1.114
Lower 95% CI..............: 1.002
Upper 95% CI..............: 1.239
T-value...................: 2.004077
P-value...................: 0.04539552
R^2.......................: 0.014288
Adjusted r^2..............: 0.009402
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of NT5DC2.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' NT5DC2 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: NT5DC2
Trait/outcome.............: MAC_rankNorm
Effect size...............: -0.064431
Standard error............: 0.057148
Odds ratio (effect size)..: 0.938
Lower 95% CI..............: 0.838
Upper 95% CI..............: 1.049
T-value...................: -1.127441
P-value...................: 0.259869
R^2.......................: 0.003654
Adjusted r^2..............: -0.000958
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' NT5DC2 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: NT5DC2
Trait/outcome.............: SMC_rankNorm
Effect size...............: -0.198497
Standard error............: 0.05887
Odds ratio (effect size)..: 0.82
Lower 95% CI..............: 0.731
Upper 95% CI..............: 0.92
T-value...................: -3.371776
P-value...................: 0.0007800922
R^2.......................: 0.015059
Adjusted r^2..............: 0.010488
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' NT5DC2 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: NT5DC2
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: 0.004794
Standard error............: 0.05244
Odds ratio (effect size)..: 1.005
Lower 95% CI..............: 0.907
Upper 95% CI..............: 1.114
T-value...................: 0.091424
P-value...................: 0.9271768
R^2.......................: 0.002099
Adjusted r^2..............: -0.002537
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' NT5DC2 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: NT5DC2
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: 0.003965
Standard error............: 0.05687
Odds ratio (effect size)..: 1.004
Lower 95% CI..............: 0.898
Upper 95% CI..............: 1.122
T-value...................: 0.069714
P-value...................: 0.9444388
R^2.......................: 0.002624
Adjusted r^2..............: -0.00232
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of TGFBI.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TGFBI ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TGFBI
Trait/outcome.............: MAC_rankNorm
Effect size...............: -0.030072
Standard error............: 0.063823
Odds ratio (effect size)..: 0.97
Lower 95% CI..............: 0.856
Upper 95% CI..............: 1.1
T-value...................: -0.471178
P-value...................: 0.6376329
R^2.......................: 0.009649
Adjusted r^2..............: 0.005064
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TGFBI ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TGFBI
Trait/outcome.............: SMC_rankNorm
Effect size...............: -0.226791
Standard error............: 0.065665
Odds ratio (effect size)..: 0.797
Lower 95% CI..............: 0.701
Upper 95% CI..............: 0.907
T-value...................: -3.453775
P-value...................: 0.0005797429
R^2.......................: 0.022856
Adjusted r^2..............: 0.018322
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TGFBI ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TGFBI
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: 0.005525
Standard error............: 0.058508
Odds ratio (effect size)..: 1.006
Lower 95% CI..............: 0.897
Upper 95% CI..............: 1.128
T-value...................: 0.094441
P-value...................: 0.9247811
R^2.......................: 0.009372
Adjusted r^2..............: 0.00477
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TGFBI ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TGFBI
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: 0.002111
Standard error............: 0.063453
Odds ratio (effect size)..: 1.002
Lower 95% CI..............: 0.885
Upper 95% CI..............: 1.135
T-value...................: 0.033269
P-value...................: 0.9734681
R^2.......................: 0.008829
Adjusted r^2..............: 0.003917
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of C1QC.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' C1QC ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: C1QC
Trait/outcome.............: MAC_rankNorm
Effect size...............: 0.025493
Standard error............: 0.069697
Odds ratio (effect size)..: 1.026
Lower 95% CI..............: 0.895
Upper 95% CI..............: 1.176
T-value...................: 0.365774
P-value...................: 0.7146229
R^2.......................: 0.008583
Adjusted r^2..............: 0.003993
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' C1QC ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: C1QC
Trait/outcome.............: SMC_rankNorm
Effect size...............: -0.283741
Standard error............: 0.07159
Odds ratio (effect size)..: 0.753
Lower 95% CI..............: 0.654
Upper 95% CI..............: 0.866
T-value...................: -3.963406
P-value...................: 8.00056e-05
R^2.......................: 0.025834
Adjusted r^2..............: 0.021313
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' C1QC ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: C1QC
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: 0.077613
Standard error............: 0.063823
Odds ratio (effect size)..: 1.081
Lower 95% CI..............: 0.954
Upper 95% CI..............: 1.225
T-value...................: 1.216073
P-value...................: 0.2242903
R^2.......................: 0.009949
Adjusted r^2..............: 0.005349
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' C1QC ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: C1QC
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: 0.009869
Standard error............: 0.069375
Odds ratio (effect size)..: 1.01
Lower 95% CI..............: 0.882
Upper 95% CI..............: 1.157
T-value...................: 0.142258
P-value...................: 0.8869121
R^2.......................: 0.012561
Adjusted r^2..............: 0.007667
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
Analysis of S100A9.
- processing MAC_rankNorm
filter: removed 223 rows (20%), 869 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' S100A9 ' with ' MAC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: S100A9
Trait/outcome.............: MAC_rankNorm
Effect size...............: -0.005659
Standard error............: 0.051608
Odds ratio (effect size)..: 0.994
Lower 95% CI..............: 0.899
Upper 95% CI..............: 1.1
T-value...................: -0.109644
P-value...................: 0.9127172
R^2.......................: 0.004002
Adjusted r^2..............: -0.000609
Sample size of AE DB......: 1092
Sample size of model......: 869
Missing data %............: 20.42124
- processing SMC_rankNorm
filter: removed 225 rows (21%), 867 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' S100A9 ' with ' SMC_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: S100A9
Trait/outcome.............: SMC_rankNorm
Effect size...............: -0.228809
Standard error............: 0.052912
Odds ratio (effect size)..: 0.795
Lower 95% CI..............: 0.717
Upper 95% CI..............: 0.882
T-value...................: -4.324337
P-value...................: 1.708669e-05
R^2.......................: 0.024902
Adjusted r^2..............: 0.020377
Sample size of AE DB......: 1092
Sample size of model......: 867
Missing data %............: 20.6044
- processing MAC_SMC_ratio_rank
filter: removed 226 rows (21%), 866 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' S100A9 ' with ' MAC_SMC_ratio_rank ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: S100A9
Trait/outcome.............: MAC_SMC_ratio_rank
Effect size...............: 0.037964
Standard error............: 0.047251
Odds ratio (effect size)..: 1.039
Lower 95% CI..............: 0.947
Upper 95% CI..............: 1.139
T-value...................: 0.803453
P-value...................: 0.4219345
R^2.......................: 0.004687
Adjusted r^2..............: 6.3e-05
Sample size of AE DB......: 1092
Sample size of model......: 866
Missing data %............: 20.69597
- processing VesselDensity_rankNorm
filter: removed 280 rows (26%), 812 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' S100A9 ' with ' VesselDensity_rankNorm ' .
Collecting data.
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: S100A9
Trait/outcome.............: VesselDensity_rankNorm
Effect size...............: 0.035344
Standard error............: 0.051349
Odds ratio (effect size)..: 1.036
Lower 95% CI..............: 0.937
Upper 95% CI..............: 1.146
T-value...................: 0.688305
P-value...................: 0.4914583
R^2.......................: 0.005005
Adjusted r^2..............: 7.3e-05
Sample size of AE DB......: 1092
Sample size of model......: 812
Missing data %............: 25.64103
cat("Edit the column names...\n")
Edit the column names...
colnames(GLM.results) = c("Dataset", "Predictor", "Trait",
"Beta", "s.e.m.",
"OR", "low95CI", "up95CI",
"T-value", "P-value", "r^2", "r^2_adj", "N", "Model_N", "Perc_Miss")
cat("Correct the variable types...\n")
Correct the variable types...
GLM.results$Beta <- as.numeric(GLM.results$Beta)
GLM.results$s.e.m. <- as.numeric(GLM.results$s.e.m.)
GLM.results$OR <- as.numeric(GLM.results$OR)
GLM.results$low95CI <- as.numeric(GLM.results$low95CI)
GLM.results$up95CI <- as.numeric(GLM.results$up95CI)
GLM.results$`T-value` <- as.numeric(GLM.results$`T-value`)
GLM.results$`P-value` <- as.numeric(GLM.results$`P-value`)
GLM.results$`r^2` <- as.numeric(GLM.results$`r^2`)
GLM.results$`r^2_adj` <- as.numeric(GLM.results$`r^2_adj`)
GLM.results$`N` <- as.numeric(GLM.results$`N`)
GLM.results$`Model_N` <- as.numeric(GLM.results$`Model_N`)
GLM.results$`Perc_Miss` <- as.numeric(GLM.results$`Perc_Miss`)
# Save the data
cat("Writing results to Excel-file...\n")
Writing results to Excel-file...
### Univariate
library(openxlsx)
write.xlsx(GLM.results,
file = paste0(OUT_loc, "/",Today,".AERNASE.clin.targets.Con.Uni.",TRAIT_OF_INTEREST,".PlaquePhenotypes.RANK.MODEL1.xlsx"),
rowNames = FALSE, colNames = TRUE, sheetName = "Con.Uni.PlaquePheno")
# Removing intermediates
cat("Removing intermediate files...\n")
Removing intermediate files...
rm(TRAIT, trait, currentDF, GLM.results, GLM.results.TEMP, fit, model_step)
Binary plaque traits
Analysis of binary plaque traits as a function of plaque
CONVOCALS_downstream expression levels.
GLM.results <- data.frame(matrix(NA, ncol = 16, nrow = 0))
for (target_of_interest in 1:length(TRAITS.TARGET.RANK)) {
TARGET = TRAITS.TARGET.RANK[target_of_interest]
cat(paste0("\nAnalysis of ",TARGET,".\n"))
for (trait in 1:length(TRAITS.BIN)) {
TRAIT = TRAITS.BIN[trait]
cat(paste0("\n- processing ",TRAIT,"\n\n"))
currentDF <- as.data.frame(AERNASE.clin.targets %>%
dplyr::select(., TARGET, TRAIT, COVARIATES_M1) %>%
filter(complete.cases(.))) %>%
filter_if(~is.numeric(.), all_vars(!is.infinite(.)))
# for debug
# print(DT::datatable(currentDF))
# print(nrow(currentDF))
# print(str(currentDF))
# print(class(currentDF[,TRAIT]))
### univariate
# fit <- glm(as.factor(currentDF[,TRAIT]) ~ currentDF[,TARGET] + Age + Gender + ORdate_year,
# data = currentDF, family = binomial(link = "logit"))
fit <- glm(as.factor(currentDF[,TRAIT]) ~ currentDF[,TARGET] + Age + Gender + ORdate_epoch,
data = currentDF, family = binomial(link = "logit"))
model_step <- stepAIC(fit, direction = "both", trace = FALSE)
# print(model_step)
# print(summary(fit))
GLM.results.TEMP <- data.frame(matrix(NA, ncol = 16, nrow = 0))
GLM.results.TEMP[1,] = GLM.BIN(fit, "AERNASE.clin.targets", TARGET, TRAIT, verbose = TRUE)
GLM.results = rbind(GLM.results, GLM.results.TEMP)
}
}
Analysis of SCGB3A2.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SCGB3A2 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SCGB3A2
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.060976
Standard error............: 0.056214
Odds ratio (effect size)..: 0.941
Lower 95% CI..............: 0.843
Upper 95% CI..............: 1.05
Z-value...................: -1.0847
P-value...................: 0.2780547
Hosmer and Lemeshow r^2...: 0.090537
Cox and Snell r^2.........: 0.117842
Nagelkerke's pseudo r^2...: 0.157196
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SCGB3A2 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SCGB3A2
Trait/outcome.............: CollagenPlaque
Effect size...............: 0.014859
Standard error............: 0.066871
Odds ratio (effect size)..: 1.015
Lower 95% CI..............: 0.89
Upper 95% CI..............: 1.157
Z-value...................: 0.222209
P-value...................: 0.8241514
Hosmer and Lemeshow r^2...: 0.004662
Cox and Snell r^2.........: 0.004731
Nagelkerke's pseudo r^2...: 0.007411
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SCGB3A2 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SCGB3A2
Trait/outcome.............: Fat10Perc
Effect size...............: -0.282835
Standard error............: 0.06191
Odds ratio (effect size)..: 0.754
Lower 95% CI..............: 0.668
Upper 95% CI..............: 0.851
Z-value...................: -4.568451
P-value...................: 4.913414e-06
Hosmer and Lemeshow r^2...: 0.067559
Cox and Snell r^2.........: 0.073806
Nagelkerke's pseudo r^2...: 0.108771
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SCGB3A2 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SCGB3A2
Trait/outcome.............: IPH
Effect size...............: -0.094332
Standard error............: 0.055804
Odds ratio (effect size)..: 0.91
Lower 95% CI..............: 0.816
Upper 95% CI..............: 1.015
Z-value...................: -1.690432
P-value...................: 0.09094541
Hosmer and Lemeshow r^2...: 0.034883
Cox and Snell r^2.........: 0.045762
Nagelkerke's pseudo r^2...: 0.061934
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SCGB3A2 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SCGB3A2
Trait/outcome.............: MAC_binned
Effect size...............: 0.002153
Standard error............: 0.05538
Odds ratio (effect size)..: 1.002
Lower 95% CI..............: 0.899
Upper 95% CI..............: 1.117
Z-value...................: 0.038884
P-value...................: 0.9689828
Hosmer and Lemeshow r^2...: 0.02326
Cox and Snell r^2.........: 0.031406
Nagelkerke's pseudo r^2...: 0.042079
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SCGB3A2 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SCGB3A2
Trait/outcome.............: SMC_binned
Effect size...............: 0.164514
Standard error............: 0.059905
Odds ratio (effect size)..: 1.179
Lower 95% CI..............: 1.048
Upper 95% CI..............: 1.326
Z-value...................: 2.746263
P-value...................: 0.006027838
Hosmer and Lemeshow r^2...: 0.025596
Cox and Snell r^2.........: 0.032035
Nagelkerke's pseudo r^2...: 0.044509
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of LIX1.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LIX1 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LIX1
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.033649
Standard error............: 0.075266
Odds ratio (effect size)..: 0.967
Lower 95% CI..............: 0.834
Upper 95% CI..............: 1.121
Z-value...................: -0.447073
P-value...................: 0.6548224
Hosmer and Lemeshow r^2...: 0.089801
Cox and Snell r^2.........: 0.116942
Nagelkerke's pseudo r^2...: 0.155996
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LIX1 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LIX1
Trait/outcome.............: CollagenPlaque
Effect size...............: 0.172085
Standard error............: 0.088799
Odds ratio (effect size)..: 1.188
Lower 95% CI..............: 0.998
Upper 95% CI..............: 1.414
Z-value...................: 1.937902
P-value...................: 0.05263517
Hosmer and Lemeshow r^2...: 0.008603
Cox and Snell r^2.........: 0.008713
Nagelkerke's pseudo r^2...: 0.013648
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LIX1 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LIX1
Trait/outcome.............: Fat10Perc
Effect size...............: -0.592081
Standard error............: 0.0883
Odds ratio (effect size)..: 0.553
Lower 95% CI..............: 0.465
Upper 95% CI..............: 0.658
Z-value...................: -6.705349
P-value...................: 2.009259e-11
Hosmer and Lemeshow r^2...: 0.092793
Cox and Snell r^2.........: 0.099953
Nagelkerke's pseudo r^2...: 0.147306
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LIX1 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LIX1
Trait/outcome.............: IPH
Effect size...............: -0.28004
Standard error............: 0.075776
Odds ratio (effect size)..: 0.756
Lower 95% CI..............: 0.651
Upper 95% CI..............: 0.877
Z-value...................: -3.695656
P-value...................: 0.0002193199
Hosmer and Lemeshow r^2...: 0.043706
Cox and Snell r^2.........: 0.057001
Nagelkerke's pseudo r^2...: 0.077143
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LIX1 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LIX1
Trait/outcome.............: MAC_binned
Effect size...............: -0.296724
Standard error............: 0.07516
Odds ratio (effect size)..: 0.743
Lower 95% CI..............: 0.641
Upper 95% CI..............: 0.861
Z-value...................: -3.947885
P-value...................: 7.884455e-05
Hosmer and Lemeshow r^2...: 0.035818
Cox and Snell r^2.........: 0.047949
Nagelkerke's pseudo r^2...: 0.064244
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LIX1 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LIX1
Trait/outcome.............: SMC_binned
Effect size...............: 0.350429
Standard error............: 0.079028
Odds ratio (effect size)..: 1.42
Lower 95% CI..............: 1.216
Upper 95% CI..............: 1.658
Z-value...................: 4.434213
P-value...................: 9.240925e-06
Hosmer and Lemeshow r^2...: 0.036209
Cox and Snell r^2.........: 0.045014
Nagelkerke's pseudo r^2...: 0.062542
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of IGSF9B.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' IGSF9B ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: IGSF9B
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.017009
Standard error............: 0.05711
Odds ratio (effect size)..: 0.983
Lower 95% CI..............: 0.879
Upper 95% CI..............: 1.1
Z-value...................: -0.297828
P-value...................: 0.7658342
Hosmer and Lemeshow r^2...: 0.089717
Cox and Snell r^2.........: 0.116839
Nagelkerke's pseudo r^2...: 0.155859
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' IGSF9B ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: IGSF9B
Trait/outcome.............: CollagenPlaque
Effect size...............: -0.01389
Standard error............: 0.067663
Odds ratio (effect size)..: 0.986
Lower 95% CI..............: 0.864
Upper 95% CI..............: 1.126
Z-value...................: -0.205279
P-value...................: 0.8373542
Hosmer and Lemeshow r^2...: 0.004654
Cox and Snell r^2.........: 0.004723
Nagelkerke's pseudo r^2...: 0.007398
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' IGSF9B ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: IGSF9B
Trait/outcome.............: Fat10Perc
Effect size...............: -0.209493
Standard error............: 0.0626
Odds ratio (effect size)..: 0.811
Lower 95% CI..............: 0.717
Upper 95% CI..............: 0.917
Z-value...................: -3.346531
P-value...................: 0.0008182939
Hosmer and Lemeshow r^2...: 0.058516
Cox and Snell r^2.........: 0.064251
Nagelkerke's pseudo r^2...: 0.094691
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' IGSF9B ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: IGSF9B
Trait/outcome.............: IPH
Effect size...............: -0.050611
Standard error............: 0.056754
Odds ratio (effect size)..: 0.951
Lower 95% CI..............: 0.851
Upper 95% CI..............: 1.063
Z-value...................: -0.891763
P-value...................: 0.37252
Hosmer and Lemeshow r^2...: 0.03324
Cox and Snell r^2.........: 0.043654
Nagelkerke's pseudo r^2...: 0.059081
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' IGSF9B ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: IGSF9B
Trait/outcome.............: MAC_binned
Effect size...............: -0.058101
Standard error............: 0.055958
Odds ratio (effect size)..: 0.944
Lower 95% CI..............: 0.846
Upper 95% CI..............: 1.053
Z-value...................: -1.0383
P-value...................: 0.2991306
Hosmer and Lemeshow r^2...: 0.024108
Cox and Snell r^2.........: 0.032532
Nagelkerke's pseudo r^2...: 0.043587
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' IGSF9B ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: IGSF9B
Trait/outcome.............: SMC_binned
Effect size...............: 0.131452
Standard error............: 0.060514
Odds ratio (effect size)..: 1.14
Lower 95% CI..............: 1.013
Upper 95% CI..............: 1.284
Z-value...................: 2.172244
P-value...................: 0.02983724
Hosmer and Lemeshow r^2...: 0.02309
Cox and Snell r^2.........: 0.028944
Nagelkerke's pseudo r^2...: 0.040215
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of ALB.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ALB ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ALB
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.098463
Standard error............: 0.070056
Odds ratio (effect size)..: 0.906
Lower 95% CI..............: 0.79
Upper 95% CI..............: 1.04
Z-value...................: -1.405479
P-value...................: 0.1598789
Hosmer and Lemeshow r^2...: 0.091151
Cox and Snell r^2.........: 0.118591
Nagelkerke's pseudo r^2...: 0.158196
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ALB ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ALB
Trait/outcome.............: CollagenPlaque
Effect size...............: 0.052742
Standard error............: 0.081949
Odds ratio (effect size)..: 1.054
Lower 95% CI..............: 0.898
Upper 95% CI..............: 1.238
Z-value...................: 0.643592
P-value...................: 0.5198399
Hosmer and Lemeshow r^2...: 0.005046
Cox and Snell r^2.........: 0.005119
Nagelkerke's pseudo r^2...: 0.008019
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ALB ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ALB
Trait/outcome.............: Fat10Perc
Effect size...............: -0.475677
Standard error............: 0.084404
Odds ratio (effect size)..: 0.621
Lower 95% CI..............: 0.527
Upper 95% CI..............: 0.733
Z-value...................: -5.63571
P-value...................: 1.743385e-08
Hosmer and Lemeshow r^2...: 0.079741
Cox and Snell r^2.........: 0.086522
Nagelkerke's pseudo r^2...: 0.127512
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ALB ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ALB
Trait/outcome.............: IPH
Effect size...............: -0.203012
Standard error............: 0.070944
Odds ratio (effect size)..: 0.816
Lower 95% CI..............: 0.71
Upper 95% CI..............: 0.938
Z-value...................: -2.861587
P-value...................: 0.004215256
Hosmer and Lemeshow r^2...: 0.03928
Cox and Snell r^2.........: 0.05138
Nagelkerke's pseudo r^2...: 0.069536
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ALB ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ALB
Trait/outcome.............: MAC_binned
Effect size...............: -0.244373
Standard error............: 0.069788
Odds ratio (effect size)..: 0.783
Lower 95% CI..............: 0.683
Upper 95% CI..............: 0.898
Z-value...................: -3.501664
P-value...................: 0.0004623625
Hosmer and Lemeshow r^2...: 0.033201
Cox and Snell r^2.........: 0.044526
Nagelkerke's pseudo r^2...: 0.059657
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ALB ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ALB
Trait/outcome.............: SMC_binned
Effect size...............: 0.110518
Standard error............: 0.07054
Odds ratio (effect size)..: 1.117
Lower 95% CI..............: 0.973
Upper 95% CI..............: 1.282
Z-value...................: 1.566745
P-value...................: 0.1171743
Hosmer and Lemeshow r^2...: 0.021077
Cox and Snell r^2.........: 0.026454
Nagelkerke's pseudo r^2...: 0.036756
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of OR10A4.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' OR10A4 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: OR10A4
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.066354
Standard error............: 0.06469
Odds ratio (effect size)..: 0.936
Lower 95% CI..............: 0.824
Upper 95% CI..............: 1.062
Z-value...................: -1.025724
P-value...................: 0.3050217
Hosmer and Lemeshow r^2...: 0.090447
Cox and Snell r^2.........: 0.117731
Nagelkerke's pseudo r^2...: 0.157049
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' OR10A4 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: OR10A4
Trait/outcome.............: CollagenPlaque
Effect size...............: 0.06206
Standard error............: 0.075486
Odds ratio (effect size)..: 1.064
Lower 95% CI..............: 0.918
Upper 95% CI..............: 1.234
Z-value...................: 0.822138
P-value...................: 0.4109985
Hosmer and Lemeshow r^2...: 0.00532
Cox and Snell r^2.........: 0.005398
Nagelkerke's pseudo r^2...: 0.008455
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' OR10A4 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: OR10A4
Trait/outcome.............: Fat10Perc
Effect size...............: -0.46289
Standard error............: 0.078261
Odds ratio (effect size)..: 0.629
Lower 95% CI..............: 0.54
Upper 95% CI..............: 0.734
Z-value...................: -5.914686
P-value...................: 3.325095e-09
Hosmer and Lemeshow r^2...: 0.08312
Cox and Snell r^2.........: 0.090019
Nagelkerke's pseudo r^2...: 0.132666
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' OR10A4 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: OR10A4
Trait/outcome.............: IPH
Effect size...............: -0.186198
Standard error............: 0.065422
Odds ratio (effect size)..: 0.83
Lower 95% CI..............: 0.73
Upper 95% CI..............: 0.944
Z-value...................: -2.846126
P-value...................: 0.004425465
Hosmer and Lemeshow r^2...: 0.0392
Cox and Snell r^2.........: 0.051278
Nagelkerke's pseudo r^2...: 0.069398
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' OR10A4 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: OR10A4
Trait/outcome.............: MAC_binned
Effect size...............: -0.191658
Standard error............: 0.064343
Odds ratio (effect size)..: 0.826
Lower 95% CI..............: 0.728
Upper 95% CI..............: 0.937
Z-value...................: -2.978691
P-value...................: 0.002894829
Hosmer and Lemeshow r^2...: 0.030396
Cox and Snell r^2.........: 0.040841
Nagelkerke's pseudo r^2...: 0.05472
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' OR10A4 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: OR10A4
Trait/outcome.............: SMC_binned
Effect size...............: 0.13207
Standard error............: 0.065428
Odds ratio (effect size)..: 1.141
Lower 95% CI..............: 1.004
Upper 95% CI..............: 1.297
Z-value...................: 2.018537
P-value...................: 0.04353534
Hosmer and Lemeshow r^2...: 0.022457
Cox and Snell r^2.........: 0.028161
Nagelkerke's pseudo r^2...: 0.039127
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of RASEF.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' RASEF ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: RASEF
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.041214
Standard error............: 0.069104
Odds ratio (effect size)..: 0.96
Lower 95% CI..............: 0.838
Upper 95% CI..............: 1.099
Z-value...................: -0.596404
P-value...................: 0.5509052
Hosmer and Lemeshow r^2...: 0.089919
Cox and Snell r^2.........: 0.117086
Nagelkerke's pseudo r^2...: 0.156188
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' RASEF ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: RASEF
Trait/outcome.............: CollagenPlaque
Effect size...............: -0.059181
Standard error............: 0.082383
Odds ratio (effect size)..: 0.943
Lower 95% CI..............: 0.802
Upper 95% CI..............: 1.108
Z-value...................: -0.718366
P-value...................: 0.4725314
Hosmer and Lemeshow r^2...: 0.005158
Cox and Snell r^2.........: 0.005233
Nagelkerke's pseudo r^2...: 0.008197
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' RASEF ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: RASEF
Trait/outcome.............: Fat10Perc
Effect size...............: -0.566007
Standard error............: 0.088969
Odds ratio (effect size)..: 0.568
Lower 95% CI..............: 0.477
Upper 95% CI..............: 0.676
Z-value...................: -6.361873
P-value...................: 1.993077e-10
Hosmer and Lemeshow r^2...: 0.089454
Cox and Snell r^2.........: 0.096536
Nagelkerke's pseudo r^2...: 0.14227
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' RASEF ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: RASEF
Trait/outcome.............: IPH
Effect size...............: -0.132295
Standard error............: 0.070078
Odds ratio (effect size)..: 0.876
Lower 95% CI..............: 0.764
Upper 95% CI..............: 1.005
Z-value...................: -1.887816
P-value...................: 0.05905066
Hosmer and Lemeshow r^2...: 0.035494
Cox and Snell r^2.........: 0.046544
Nagelkerke's pseudo r^2...: 0.062991
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' RASEF ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: RASEF
Trait/outcome.............: MAC_binned
Effect size...............: -0.104899
Standard error............: 0.06823
Odds ratio (effect size)..: 0.9
Lower 95% CI..............: 0.788
Upper 95% CI..............: 1.029
Z-value...................: -1.537435
P-value...................: 0.1241869
Hosmer and Lemeshow r^2...: 0.025141
Cox and Snell r^2.........: 0.033902
Nagelkerke's pseudo r^2...: 0.045423
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' RASEF ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: RASEF
Trait/outcome.............: SMC_binned
Effect size...............: 0.111816
Standard error............: 0.070037
Odds ratio (effect size)..: 1.118
Lower 95% CI..............: 0.975
Upper 95% CI..............: 1.283
Z-value...................: 1.596527
P-value...................: 0.1103712
Hosmer and Lemeshow r^2...: 0.021154
Cox and Snell r^2.........: 0.02655
Nagelkerke's pseudo r^2...: 0.036888
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of NEDD4.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' NEDD4 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: NEDD4
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.058379
Standard error............: 0.072513
Odds ratio (effect size)..: 0.943
Lower 95% CI..............: 0.818
Upper 95% CI..............: 1.087
Z-value...................: -0.805088
P-value...................: 0.4207688
Hosmer and Lemeshow r^2...: 0.09014
Cox and Snell r^2.........: 0.117357
Nagelkerke's pseudo r^2...: 0.156549
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' NEDD4 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: NEDD4
Trait/outcome.............: CollagenPlaque
Effect size...............: 0.031623
Standard error............: 0.085125
Odds ratio (effect size)..: 1.032
Lower 95% CI..............: 0.874
Upper 95% CI..............: 1.22
Z-value...................: 0.371494
P-value...................: 0.7102699
Hosmer and Lemeshow r^2...: 0.004755
Cox and Snell r^2.........: 0.004825
Nagelkerke's pseudo r^2...: 0.007558
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' NEDD4 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: NEDD4
Trait/outcome.............: Fat10Perc
Effect size...............: -0.539083
Standard error............: 0.091295
Odds ratio (effect size)..: 0.583
Lower 95% CI..............: 0.488
Upper 95% CI..............: 0.698
Z-value...................: -5.904862
P-value...................: 3.529431e-09
Hosmer and Lemeshow r^2...: 0.083371
Cox and Snell r^2.........: 0.090277
Nagelkerke's pseudo r^2...: 0.133047
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' NEDD4 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: NEDD4
Trait/outcome.............: IPH
Effect size...............: -0.174262
Standard error............: 0.073548
Odds ratio (effect size)..: 0.84
Lower 95% CI..............: 0.727
Upper 95% CI..............: 0.97
Z-value...................: -2.36936
P-value...................: 0.01781891
Hosmer and Lemeshow r^2...: 0.037164
Cox and Snell r^2.........: 0.048681
Nagelkerke's pseudo r^2...: 0.065883
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' NEDD4 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: NEDD4
Trait/outcome.............: MAC_binned
Effect size...............: -0.160517
Standard error............: 0.071803
Odds ratio (effect size)..: 0.852
Lower 95% CI..............: 0.74
Upper 95% CI..............: 0.98
Z-value...................: -2.235535
P-value...................: 0.02538222
Hosmer and Lemeshow r^2...: 0.027253
Cox and Snell r^2.........: 0.036698
Nagelkerke's pseudo r^2...: 0.049168
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' NEDD4 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: NEDD4
Trait/outcome.............: SMC_binned
Effect size...............: 0.100734
Standard error............: 0.073252
Odds ratio (effect size)..: 1.106
Lower 95% CI..............: 0.958
Upper 95% CI..............: 1.277
Z-value...................: 1.375186
P-value...................: 0.1690739
Hosmer and Lemeshow r^2...: 0.020597
Cox and Snell r^2.........: 0.02586
Nagelkerke's pseudo r^2...: 0.035929
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of TCL1A.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TCL1A ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TCL1A
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.011426
Standard error............: 0.082362
Odds ratio (effect size)..: 0.989
Lower 95% CI..............: 0.841
Upper 95% CI..............: 1.162
Z-value...................: -0.138726
P-value...................: 0.8896667
Hosmer and Lemeshow r^2...: 0.089665
Cox and Snell r^2.........: 0.116775
Nagelkerke's pseudo r^2...: 0.155773
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TCL1A ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TCL1A
Trait/outcome.............: CollagenPlaque
Effect size...............: 0.232564
Standard error............: 0.09822
Odds ratio (effect size)..: 1.262
Lower 95% CI..............: 1.041
Upper 95% CI..............: 1.53
Z-value...................: 2.367777
P-value...................: 0.01789531
Hosmer and Lemeshow r^2...: 0.010602
Cox and Snell r^2.........: 0.010727
Nagelkerke's pseudo r^2...: 0.016802
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TCL1A ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TCL1A
Trait/outcome.............: Fat10Perc
Effect size...............: -0.642105
Standard error............: 0.09678
Odds ratio (effect size)..: 0.526
Lower 95% CI..............: 0.435
Upper 95% CI..............: 0.636
Z-value...................: -6.634708
P-value...................: 3.251455e-11
Hosmer and Lemeshow r^2...: 0.091665
Cox and Snell r^2.........: 0.0988
Nagelkerke's pseudo r^2...: 0.145607
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TCL1A ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TCL1A
Trait/outcome.............: IPH
Effect size...............: -0.306825
Standard error............: 0.083076
Odds ratio (effect size)..: 0.736
Lower 95% CI..............: 0.625
Upper 95% CI..............: 0.866
Z-value...................: -3.693304
P-value...................: 0.000221359
Hosmer and Lemeshow r^2...: 0.043687
Cox and Snell r^2.........: 0.056977
Nagelkerke's pseudo r^2...: 0.077111
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TCL1A ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TCL1A
Trait/outcome.............: MAC_binned
Effect size...............: -0.305656
Standard error............: 0.082036
Odds ratio (effect size)..: 0.737
Lower 95% CI..............: 0.627
Upper 95% CI..............: 0.865
Z-value...................: -3.72589
P-value...................: 0.000194627
Hosmer and Lemeshow r^2...: 0.034416
Cox and Snell r^2.........: 0.046116
Nagelkerke's pseudo r^2...: 0.061787
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TCL1A ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TCL1A
Trait/outcome.............: SMC_binned
Effect size...............: 0.414638
Standard error............: 0.087418
Odds ratio (effect size)..: 1.514
Lower 95% CI..............: 1.275
Upper 95% CI..............: 1.797
Z-value...................: 4.743157
P-value...................: 2.104126e-06
Hosmer and Lemeshow r^2...: 0.038834
Cox and Snell r^2.........: 0.048198
Nagelkerke's pseudo r^2...: 0.066966
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of FBXO15.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FBXO15 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FBXO15
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.098527
Standard error............: 0.072481
Odds ratio (effect size)..: 0.906
Lower 95% CI..............: 0.786
Upper 95% CI..............: 1.044
Z-value...................: -1.359352
P-value...................: 0.1740349
Hosmer and Lemeshow r^2...: 0.091055
Cox and Snell r^2.........: 0.118474
Nagelkerke's pseudo r^2...: 0.158039
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FBXO15 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FBXO15
Trait/outcome.............: CollagenPlaque
Effect size...............: -0.020066
Standard error............: 0.085566
Odds ratio (effect size)..: 0.98
Lower 95% CI..............: 0.829
Upper 95% CI..............: 1.159
Z-value...................: -0.234509
P-value...................: 0.81459
Hosmer and Lemeshow r^2...: 0.004668
Cox and Snell r^2.........: 0.004737
Nagelkerke's pseudo r^2...: 0.00742
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FBXO15 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FBXO15
Trait/outcome.............: Fat10Perc
Effect size...............: -0.553272
Standard error............: 0.093525
Odds ratio (effect size)..: 0.575
Lower 95% CI..............: 0.479
Upper 95% CI..............: 0.691
Z-value...................: -5.915782
P-value...................: 3.303019e-09
Hosmer and Lemeshow r^2...: 0.084283
Cox and Snell r^2.........: 0.091218
Nagelkerke's pseudo r^2...: 0.134433
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FBXO15 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FBXO15
Trait/outcome.............: IPH
Effect size...............: -0.166016
Standard error............: 0.073571
Odds ratio (effect size)..: 0.847
Lower 95% CI..............: 0.733
Upper 95% CI..............: 0.978
Z-value...................: -2.256531
P-value...................: 0.02403741
Hosmer and Lemeshow r^2...: 0.036751
Cox and Snell r^2.........: 0.048152
Nagelkerke's pseudo r^2...: 0.065168
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FBXO15 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FBXO15
Trait/outcome.............: MAC_binned
Effect size...............: -0.199843
Standard error............: 0.072244
Odds ratio (effect size)..: 0.819
Lower 95% CI..............: 0.711
Upper 95% CI..............: 0.943
Z-value...................: -2.766236
P-value...................: 0.00567075
Hosmer and Lemeshow r^2...: 0.029433
Cox and Snell r^2.........: 0.039573
Nagelkerke's pseudo r^2...: 0.053021
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FBXO15 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FBXO15
Trait/outcome.............: SMC_binned
Effect size...............: 0.129649
Standard error............: 0.072609
Odds ratio (effect size)..: 1.138
Lower 95% CI..............: 0.987
Upper 95% CI..............: 1.313
Z-value...................: 1.785576
P-value...................: 0.07416788
Hosmer and Lemeshow r^2...: 0.021691
Cox and Snell r^2.........: 0.027214
Nagelkerke's pseudo r^2...: 0.037811
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of F5.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' F5 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: F5
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.042929
Standard error............: 0.07287
Odds ratio (effect size)..: 0.958
Lower 95% CI..............: 0.83
Upper 95% CI..............: 1.105
Z-value...................: -0.58912
P-value...................: 0.5557806
Hosmer and Lemeshow r^2...: 0.089912
Cox and Snell r^2.........: 0.117078
Nagelkerke's pseudo r^2...: 0.156177
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' F5 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: F5
Trait/outcome.............: CollagenPlaque
Effect size...............: 0.025226
Standard error............: 0.086273
Odds ratio (effect size)..: 1.026
Lower 95% CI..............: 0.866
Upper 95% CI..............: 1.214
Z-value...................: 0.292396
P-value...................: 0.7699839
Hosmer and Lemeshow r^2...: 0.0047
Cox and Snell r^2.........: 0.004769
Nagelkerke's pseudo r^2...: 0.007471
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' F5 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: F5
Trait/outcome.............: Fat10Perc
Effect size...............: -0.589849
Standard error............: 0.091732
Odds ratio (effect size)..: 0.554
Lower 95% CI..............: 0.463
Upper 95% CI..............: 0.664
Z-value...................: -6.430145
P-value...................: 1.274824e-10
Hosmer and Lemeshow r^2...: 0.089749
Cox and Snell r^2.........: 0.096839
Nagelkerke's pseudo r^2...: 0.142717
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' F5 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: F5
Trait/outcome.............: IPH
Effect size...............: -0.142143
Standard error............: 0.073895
Odds ratio (effect size)..: 0.867
Lower 95% CI..............: 0.751
Upper 95% CI..............: 1.003
Z-value...................: -1.923563
P-value...................: 0.0544094
Hosmer and Lemeshow r^2...: 0.035592
Cox and Snell r^2.........: 0.046671
Nagelkerke's pseudo r^2...: 0.063163
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' F5 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: F5
Trait/outcome.............: MAC_binned
Effect size...............: -0.197789
Standard error............: 0.073026
Odds ratio (effect size)..: 0.821
Lower 95% CI..............: 0.711
Upper 95% CI..............: 0.947
Z-value...................: -2.708476
P-value...................: 0.006759303
Hosmer and Lemeshow r^2...: 0.029149
Cox and Snell r^2.........: 0.039199
Nagelkerke's pseudo r^2...: 0.05252
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' F5 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: F5
Trait/outcome.............: SMC_binned
Effect size...............: 0.144548
Standard error............: 0.074321
Odds ratio (effect size)..: 1.156
Lower 95% CI..............: 0.999
Upper 95% CI..............: 1.337
Z-value...................: 1.944908
P-value...................: 0.051786
Hosmer and Lemeshow r^2...: 0.022209
Cox and Snell r^2.........: 0.027855
Nagelkerke's pseudo r^2...: 0.038702
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of TMEM212.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TMEM212 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TMEM212
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.08514
Standard error............: 0.075212
Odds ratio (effect size)..: 0.918
Lower 95% CI..............: 0.793
Upper 95% CI..............: 1.064
Z-value...................: -1.132003
P-value...................: 0.2576331
Hosmer and Lemeshow r^2...: 0.090622
Cox and Snell r^2.........: 0.117945
Nagelkerke's pseudo r^2...: 0.157334
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TMEM212 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TMEM212
Trait/outcome.............: CollagenPlaque
Effect size...............: 0.050226
Standard error............: 0.087653
Odds ratio (effect size)..: 1.052
Lower 95% CI..............: 0.886
Upper 95% CI..............: 1.249
Z-value...................: 0.573008
P-value...................: 0.5666394
Hosmer and Lemeshow r^2...: 0.004955
Cox and Snell r^2.........: 0.005027
Nagelkerke's pseudo r^2...: 0.007875
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TMEM212 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TMEM212
Trait/outcome.............: Fat10Perc
Effect size...............: -0.623947
Standard error............: 0.09676
Odds ratio (effect size)..: 0.536
Lower 95% CI..............: 0.443
Upper 95% CI..............: 0.648
Z-value...................: -6.448384
P-value...................: 1.130492e-10
Hosmer and Lemeshow r^2...: 0.091093
Cox and Snell r^2.........: 0.098215
Nagelkerke's pseudo r^2...: 0.144745
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TMEM212 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TMEM212
Trait/outcome.............: IPH
Effect size...............: -0.204489
Standard error............: 0.076531
Odds ratio (effect size)..: 0.815
Lower 95% CI..............: 0.702
Upper 95% CI..............: 0.947
Z-value...................: -2.671991
P-value...................: 0.007540258
Hosmer and Lemeshow r^2...: 0.038436
Cox and Snell r^2.........: 0.050304
Nagelkerke's pseudo r^2...: 0.068081
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TMEM212 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TMEM212
Trait/outcome.............: MAC_binned
Effect size...............: -0.203828
Standard error............: 0.074514
Odds ratio (effect size)..: 0.816
Lower 95% CI..............: 0.705
Upper 95% CI..............: 0.944
Z-value...................: -2.735445
P-value...................: 0.006229597
Hosmer and Lemeshow r^2...: 0.029281
Cox and Snell r^2.........: 0.039373
Nagelkerke's pseudo r^2...: 0.052753
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TMEM212 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TMEM212
Trait/outcome.............: SMC_binned
Effect size...............: 0.163038
Standard error............: 0.075351
Odds ratio (effect size)..: 1.177
Lower 95% CI..............: 1.015
Upper 95% CI..............: 1.364
Z-value...................: 2.163716
P-value...................: 0.03048614
Hosmer and Lemeshow r^2...: 0.022964
Cox and Snell r^2.........: 0.028788
Nagelkerke's pseudo r^2...: 0.039998
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of PTPRD.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' PTPRD ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: PTPRD
Trait/outcome.............: CalcificationPlaque
Effect size...............: 0.076859
Standard error............: 0.125987
Odds ratio (effect size)..: 1.08
Lower 95% CI..............: 0.844
Upper 95% CI..............: 1.382
Z-value...................: 0.610054
P-value...................: 0.541826
Hosmer and Lemeshow r^2...: 0.089931
Cox and Snell r^2.........: 0.1171
Nagelkerke's pseudo r^2...: 0.156208
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' PTPRD ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: PTPRD
Trait/outcome.............: CollagenPlaque
Effect size...............: -0.035413
Standard error............: 0.147738
Odds ratio (effect size)..: 0.965
Lower 95% CI..............: 0.723
Upper 95% CI..............: 1.289
Z-value...................: -0.239703
P-value...................: 0.8105609
Hosmer and Lemeshow r^2...: 0.004671
Cox and Snell r^2.........: 0.00474
Nagelkerke's pseudo r^2...: 0.007424
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' PTPRD ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: PTPRD
Trait/outcome.............: Fat10Perc
Effect size...............: -0.183767
Standard error............: 0.143457
Odds ratio (effect size)..: 0.832
Lower 95% CI..............: 0.628
Upper 95% CI..............: 1.102
Z-value...................: -1.280987
P-value...................: 0.2001983
Hosmer and Lemeshow r^2...: 0.049859
Cox and Snell r^2.........: 0.055013
Nagelkerke's pseudo r^2...: 0.081075
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' PTPRD ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: PTPRD
Trait/outcome.............: IPH
Effect size...............: -0.121151
Standard error............: 0.125265
Odds ratio (effect size)..: 0.886
Lower 95% CI..............: 0.693
Upper 95% CI..............: 1.132
Z-value...................: -0.967158
P-value...................: 0.3334651
Hosmer and Lemeshow r^2...: 0.033358
Cox and Snell r^2.........: 0.043806
Nagelkerke's pseudo r^2...: 0.059286
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' PTPRD ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: PTPRD
Trait/outcome.............: MAC_binned
Effect size...............: -0.156984
Standard error............: 0.123005
Odds ratio (effect size)..: 0.855
Lower 95% CI..............: 0.672
Upper 95% CI..............: 1.088
Z-value...................: -1.276241
P-value...................: 0.2018703
Hosmer and Lemeshow r^2...: 0.024553
Cox and Snell r^2.........: 0.033122
Nagelkerke's pseudo r^2...: 0.044378
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' PTPRD ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: PTPRD
Trait/outcome.............: SMC_binned
Effect size...............: -0.130025
Standard error............: 0.130156
Odds ratio (effect size)..: 0.878
Lower 95% CI..............: 0.68
Upper 95% CI..............: 1.133
Z-value...................: -0.998997
P-value...................: 0.3177962
Hosmer and Lemeshow r^2...: 0.019849
Cox and Snell r^2.........: 0.024932
Nagelkerke's pseudo r^2...: 0.034641
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of CYP46A1.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CYP46A1 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CYP46A1
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.074981
Standard error............: 0.072479
Odds ratio (effect size)..: 0.928
Lower 95% CI..............: 0.805
Upper 95% CI..............: 1.069
Z-value...................: -1.034524
P-value...................: 0.3008911
Hosmer and Lemeshow r^2...: 0.090463
Cox and Snell r^2.........: 0.11775
Nagelkerke's pseudo r^2...: 0.157074
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CYP46A1 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CYP46A1
Trait/outcome.............: CollagenPlaque
Effect size...............: 0.011841
Standard error............: 0.085286
Odds ratio (effect size)..: 1.012
Lower 95% CI..............: 0.856
Upper 95% CI..............: 1.196
Z-value...................: 0.138843
P-value...................: 0.8895738
Hosmer and Lemeshow r^2...: 0.00463
Cox and Snell r^2.........: 0.004699
Nagelkerke's pseudo r^2...: 0.00736
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CYP46A1 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CYP46A1
Trait/outcome.............: Fat10Perc
Effect size...............: -0.56117
Standard error............: 0.096002
Odds ratio (effect size)..: 0.571
Lower 95% CI..............: 0.473
Upper 95% CI..............: 0.689
Z-value...................: -5.845389
P-value...................: 5.053848e-09
Hosmer and Lemeshow r^2...: 0.083893
Cox and Snell r^2.........: 0.090816
Nagelkerke's pseudo r^2...: 0.133841
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CYP46A1 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CYP46A1
Trait/outcome.............: IPH
Effect size...............: -0.170953
Standard error............: 0.074335
Odds ratio (effect size)..: 0.843
Lower 95% CI..............: 0.729
Upper 95% CI..............: 0.975
Z-value...................: -2.299768
P-value...................: 0.02146137
Hosmer and Lemeshow r^2...: 0.036932
Cox and Snell r^2.........: 0.048384
Nagelkerke's pseudo r^2...: 0.065482
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CYP46A1 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CYP46A1
Trait/outcome.............: MAC_binned
Effect size...............: -0.207413
Standard error............: 0.072776
Odds ratio (effect size)..: 0.813
Lower 95% CI..............: 0.705
Upper 95% CI..............: 0.937
Z-value...................: -2.850007
P-value...................: 0.004371833
Hosmer and Lemeshow r^2...: 0.029845
Cox and Snell r^2.........: 0.040117
Nagelkerke's pseudo r^2...: 0.05375
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CYP46A1 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CYP46A1
Trait/outcome.............: SMC_binned
Effect size...............: 0.111652
Standard error............: 0.072658
Odds ratio (effect size)..: 1.118
Lower 95% CI..............: 0.97
Upper 95% CI..............: 1.289
Z-value...................: 1.536681
P-value...................: 0.1243715
Hosmer and Lemeshow r^2...: 0.020986
Cox and Snell r^2.........: 0.026342
Nagelkerke's pseudo r^2...: 0.0366
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of OR2T33.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' OR2T33 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: OR2T33
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.056061
Standard error............: 0.070342
Odds ratio (effect size)..: 0.945
Lower 95% CI..............: 0.824
Upper 95% CI..............: 1.085
Z-value...................: -0.796983
P-value...................: 0.4254608
Hosmer and Lemeshow r^2...: 0.090131
Cox and Snell r^2.........: 0.117345
Nagelkerke's pseudo r^2...: 0.156534
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' OR2T33 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: OR2T33
Trait/outcome.............: CollagenPlaque
Effect size...............: 0.023531
Standard error............: 0.082571
Odds ratio (effect size)..: 1.024
Lower 95% CI..............: 0.871
Upper 95% CI..............: 1.204
Z-value...................: 0.284975
P-value...................: 0.775663
Hosmer and Lemeshow r^2...: 0.004695
Cox and Snell r^2.........: 0.004765
Nagelkerke's pseudo r^2...: 0.007463
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' OR2T33 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: OR2T33
Trait/outcome.............: Fat10Perc
Effect size...............: -0.570899
Standard error............: 0.091063
Odds ratio (effect size)..: 0.565
Lower 95% CI..............: 0.473
Upper 95% CI..............: 0.675
Z-value...................: -6.269249
P-value...................: 3.62793e-10
Hosmer and Lemeshow r^2...: 0.088667
Cox and Snell r^2.........: 0.095729
Nagelkerke's pseudo r^2...: 0.141081
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' OR2T33 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: OR2T33
Trait/outcome.............: IPH
Effect size...............: -0.185993
Standard error............: 0.071896
Odds ratio (effect size)..: 0.83
Lower 95% CI..............: 0.721
Upper 95% CI..............: 0.956
Z-value...................: -2.586981
P-value...................: 0.009682103
Hosmer and Lemeshow r^2...: 0.038073
Cox and Snell r^2.........: 0.049841
Nagelkerke's pseudo r^2...: 0.067453
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' OR2T33 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: OR2T33
Trait/outcome.............: MAC_binned
Effect size...............: -0.17139
Standard error............: 0.069782
Odds ratio (effect size)..: 0.842
Lower 95% CI..............: 0.735
Upper 95% CI..............: 0.966
Z-value...................: -2.456065
P-value...................: 0.01404677
Hosmer and Lemeshow r^2...: 0.028103
Cox and Snell r^2.........: 0.037819
Nagelkerke's pseudo r^2...: 0.050671
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' OR2T33 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: OR2T33
Trait/outcome.............: SMC_binned
Effect size...............: 0.102619
Standard error............: 0.070733
Odds ratio (effect size)..: 1.108
Lower 95% CI..............: 0.965
Upper 95% CI..............: 1.273
Z-value...................: 1.45079
P-value...................: 0.1468382
Hosmer and Lemeshow r^2...: 0.020775
Cox and Snell r^2.........: 0.02608
Nagelkerke's pseudo r^2...: 0.036236
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of SORBS2.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SORBS2 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SORBS2
Trait/outcome.............: CalcificationPlaque
Effect size...............: 0.18608
Standard error............: 0.068317
Odds ratio (effect size)..: 1.205
Lower 95% CI..............: 1.054
Upper 95% CI..............: 1.377
Z-value...................: 2.723764
P-value...................: 0.006454267
Hosmer and Lemeshow r^2...: 0.095321
Cox and Snell r^2.........: 0.123667
Nagelkerke's pseudo r^2...: 0.164966
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SORBS2 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SORBS2
Trait/outcome.............: CollagenPlaque
Effect size...............: 0.047212
Standard error............: 0.080536
Odds ratio (effect size)..: 1.048
Lower 95% CI..............: 0.895
Upper 95% CI..............: 1.228
Z-value...................: 0.586227
P-value...................: 0.5577228
Hosmer and Lemeshow r^2...: 0.004976
Cox and Snell r^2.........: 0.005049
Nagelkerke's pseudo r^2...: 0.007908
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SORBS2 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SORBS2
Trait/outcome.............: Fat10Perc
Effect size...............: -0.187482
Standard error............: 0.072791
Odds ratio (effect size)..: 0.829
Lower 95% CI..............: 0.719
Upper 95% CI..............: 0.956
Z-value...................: -2.575625
P-value...................: 0.0100059
Hosmer and Lemeshow r^2...: 0.054339
Cox and Snell r^2.........: 0.059804
Nagelkerke's pseudo r^2...: 0.088137
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SORBS2 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SORBS2
Trait/outcome.............: IPH
Effect size...............: -0.091194
Standard error............: 0.06645
Odds ratio (effect size)..: 0.913
Lower 95% CI..............: 0.801
Upper 95% CI..............: 1.04
Z-value...................: -1.372359
P-value...................: 0.1699518
Hosmer and Lemeshow r^2...: 0.034104
Cox and Snell r^2.........: 0.044763
Nagelkerke's pseudo r^2...: 0.060581
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SORBS2 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SORBS2
Trait/outcome.............: MAC_binned
Effect size...............: -0.278333
Standard error............: 0.066413
Odds ratio (effect size)..: 0.757
Lower 95% CI..............: 0.665
Upper 95% CI..............: 0.862
Z-value...................: -4.190908
P-value...................: 2.778408e-05
Hosmer and Lemeshow r^2...: 0.037348
Cox and Snell r^2.........: 0.049945
Nagelkerke's pseudo r^2...: 0.066918
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SORBS2 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SORBS2
Trait/outcome.............: SMC_binned
Effect size...............: 0.076011
Standard error............: 0.070197
Odds ratio (effect size)..: 1.079
Lower 95% CI..............: 0.94
Upper 95% CI..............: 1.238
Z-value...................: 1.082829
P-value...................: 0.2788845
Hosmer and Lemeshow r^2...: 0.02
Cox and Snell r^2.........: 0.025119
Nagelkerke's pseudo r^2...: 0.0349
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of ITGA7.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ITGA7 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ITGA7
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.077291
Standard error............: 0.081752
Odds ratio (effect size)..: 0.926
Lower 95% CI..............: 0.789
Upper 95% CI..............: 1.086
Z-value...................: -0.945437
P-value...................: 0.3444359
Hosmer and Lemeshow r^2...: 0.090326
Cox and Snell r^2.........: 0.117583
Nagelkerke's pseudo r^2...: 0.156851
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ITGA7 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ITGA7
Trait/outcome.............: CollagenPlaque
Effect size...............: 0.063294
Standard error............: 0.096241
Odds ratio (effect size)..: 1.065
Lower 95% CI..............: 0.882
Upper 95% CI..............: 1.287
Z-value...................: 0.657665
P-value...................: 0.5107535
Hosmer and Lemeshow r^2...: 0.005065
Cox and Snell r^2.........: 0.005139
Nagelkerke's pseudo r^2...: 0.00805
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ITGA7 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ITGA7
Trait/outcome.............: Fat10Perc
Effect size...............: -0.488635
Standard error............: 0.09836
Odds ratio (effect size)..: 0.613
Lower 95% CI..............: 0.506
Upper 95% CI..............: 0.744
Z-value...................: -4.967812
P-value...................: 6.771242e-07
Hosmer and Lemeshow r^2...: 0.072294
Cox and Snell r^2.........: 0.078769
Nagelkerke's pseudo r^2...: 0.116087
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ITGA7 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ITGA7
Trait/outcome.............: IPH
Effect size...............: -0.138097
Standard error............: 0.08193
Odds ratio (effect size)..: 0.871
Lower 95% CI..............: 0.742
Upper 95% CI..............: 1.023
Z-value...................: -1.685548
P-value...................: 0.09188293
Hosmer and Lemeshow r^2...: 0.034889
Cox and Snell r^2.........: 0.04577
Nagelkerke's pseudo r^2...: 0.061944
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ITGA7 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ITGA7
Trait/outcome.............: MAC_binned
Effect size...............: -0.191919
Standard error............: 0.080841
Odds ratio (effect size)..: 0.825
Lower 95% CI..............: 0.704
Upper 95% CI..............: 0.967
Z-value...................: -2.374019
P-value...................: 0.01759564
Hosmer and Lemeshow r^2...: 0.027754
Cox and Snell r^2.........: 0.037359
Nagelkerke's pseudo r^2...: 0.050055
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ITGA7 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ITGA7
Trait/outcome.............: SMC_binned
Effect size...............: 0.119674
Standard error............: 0.083101
Odds ratio (effect size)..: 1.127
Lower 95% CI..............: 0.958
Upper 95% CI..............: 1.327
Z-value...................: 1.440113
P-value...................: 0.1498354
Hosmer and Lemeshow r^2...: 0.020757
Cox and Snell r^2.........: 0.026058
Nagelkerke's pseudo r^2...: 0.036205
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of FOS.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FOS ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FOS
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.01943
Standard error............: 0.040563
Odds ratio (effect size)..: 0.981
Lower 95% CI..............: 0.906
Upper 95% CI..............: 1.062
Z-value...................: -0.479008
P-value...................: 0.6319326
Hosmer and Lemeshow r^2...: 0.089823
Cox and Snell r^2.........: 0.116969
Nagelkerke's pseudo r^2...: 0.156032
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FOS ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FOS
Trait/outcome.............: CollagenPlaque
Effect size...............: -0.001773
Standard error............: 0.047527
Odds ratio (effect size)..: 0.998
Lower 95% CI..............: 0.909
Upper 95% CI..............: 1.096
Z-value...................: -0.037312
P-value...................: 0.9702359
Hosmer and Lemeshow r^2...: 0.004611
Cox and Snell r^2.........: 0.00468
Nagelkerke's pseudo r^2...: 0.00733
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FOS ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FOS
Trait/outcome.............: Fat10Perc
Effect size...............: 0.187976
Standard error............: 0.047031
Odds ratio (effect size)..: 1.207
Lower 95% CI..............: 1.101
Upper 95% CI..............: 1.323
Z-value...................: 3.996897
P-value...................: 6.417809e-05
Hosmer and Lemeshow r^2...: 0.063663
Cox and Snell r^2.........: 0.069701
Nagelkerke's pseudo r^2...: 0.102723
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FOS ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FOS
Trait/outcome.............: IPH
Effect size...............: 0.087464
Standard error............: 0.040468
Odds ratio (effect size)..: 1.091
Lower 95% CI..............: 1.008
Upper 95% CI..............: 1.181
Z-value...................: 2.161335
P-value...................: 0.03066946
Hosmer and Lemeshow r^2...: 0.036368
Cox and Snell r^2.........: 0.047663
Nagelkerke's pseudo r^2...: 0.064505
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FOS ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FOS
Trait/outcome.............: MAC_binned
Effect size...............: 0.093959
Standard error............: 0.039993
Odds ratio (effect size)..: 1.099
Lower 95% CI..............: 1.016
Upper 95% CI..............: 1.188
Z-value...................: 2.349377
P-value...................: 0.01880486
Hosmer and Lemeshow r^2...: 0.027649
Cox and Snell r^2.........: 0.03722
Nagelkerke's pseudo r^2...: 0.049869
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FOS ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FOS
Trait/outcome.............: SMC_binned
Effect size...............: -0.096808
Standard error............: 0.041449
Odds ratio (effect size)..: 0.908
Lower 95% CI..............: 0.837
Upper 95% CI..............: 0.985
Z-value...................: -2.335609
P-value...................: 0.01951165
Hosmer and Lemeshow r^2...: 0.023631
Cox and Snell r^2.........: 0.029612
Nagelkerke's pseudo r^2...: 0.041143
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of HMOX1.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' HMOX1 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: HMOX1
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.130552
Standard error............: 0.063643
Odds ratio (effect size)..: 0.878
Lower 95% CI..............: 0.775
Upper 95% CI..............: 0.994
Z-value...................: -2.051314
P-value...................: 0.04023639
Hosmer and Lemeshow r^2...: 0.092855
Cox and Snell r^2.........: 0.120668
Nagelkerke's pseudo r^2...: 0.160967
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' HMOX1 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: HMOX1
Trait/outcome.............: CollagenPlaque
Effect size...............: -0.041202
Standard error............: 0.07341
Odds ratio (effect size)..: 0.96
Lower 95% CI..............: 0.831
Upper 95% CI..............: 1.108
Z-value...................: -0.561263
P-value...................: 0.5746184
Hosmer and Lemeshow r^2...: 0.004939
Cox and Snell r^2.........: 0.005012
Nagelkerke's pseudo r^2...: 0.00785
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' HMOX1 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: HMOX1
Trait/outcome.............: Fat10Perc
Effect size...............: 0.450197
Standard error............: 0.084334
Odds ratio (effect size)..: 1.569
Lower 95% CI..............: 1.33
Upper 95% CI..............: 1.851
Z-value...................: 5.338291
P-value...................: 9.382681e-08
Hosmer and Lemeshow r^2...: 0.078738
Cox and Snell r^2.........: 0.085481
Nagelkerke's pseudo r^2...: 0.125979
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' HMOX1 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: HMOX1
Trait/outcome.............: IPH
Effect size...............: 0.224506
Standard error............: 0.065925
Odds ratio (effect size)..: 1.252
Lower 95% CI..............: 1.1
Upper 95% CI..............: 1.424
Z-value...................: 3.405467
P-value...................: 0.0006605107
Hosmer and Lemeshow r^2...: 0.04227
Cox and Snell r^2.........: 0.05518
Nagelkerke's pseudo r^2...: 0.074679
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' HMOX1 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: HMOX1
Trait/outcome.............: MAC_binned
Effect size...............: 0.266618
Standard error............: 0.06542
Odds ratio (effect size)..: 1.306
Lower 95% CI..............: 1.148
Upper 95% CI..............: 1.484
Z-value...................: 4.075488
P-value...................: 4.591796e-05
Hosmer and Lemeshow r^2...: 0.037037
Cox and Snell r^2.........: 0.049541
Nagelkerke's pseudo r^2...: 0.066376
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' HMOX1 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: HMOX1
Trait/outcome.............: SMC_binned
Effect size...............: -0.161631
Standard error............: 0.063211
Odds ratio (effect size)..: 0.851
Lower 95% CI..............: 0.752
Upper 95% CI..............: 0.963
Z-value...................: -2.557024
P-value...................: 0.01055718
Hosmer and Lemeshow r^2...: 0.024515
Cox and Snell r^2.........: 0.030702
Nagelkerke's pseudo r^2...: 0.042657
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of LAPTM5.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LAPTM5 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LAPTM5
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.06423
Standard error............: 0.032114
Odds ratio (effect size)..: 0.938
Lower 95% CI..............: 0.881
Upper 95% CI..............: 0.999
Z-value...................: -2.000054
P-value...................: 0.04549438
Hosmer and Lemeshow r^2...: 0.092676
Cox and Snell r^2.........: 0.12045
Nagelkerke's pseudo r^2...: 0.160676
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LAPTM5 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LAPTM5
Trait/outcome.............: CollagenPlaque
Effect size...............: 0.00078
Standard error............: 0.037876
Odds ratio (effect size)..: 1.001
Lower 95% CI..............: 0.929
Upper 95% CI..............: 1.078
Z-value...................: 0.020602
P-value...................: 0.983563
Hosmer and Lemeshow r^2...: 0.00461
Cox and Snell r^2.........: 0.004679
Nagelkerke's pseudo r^2...: 0.007329
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LAPTM5 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LAPTM5
Trait/outcome.............: Fat10Perc
Effect size...............: 0.211779
Standard error............: 0.037885
Odds ratio (effect size)..: 1.236
Lower 95% CI..............: 1.147
Upper 95% CI..............: 1.331
Z-value...................: 5.590039
P-value...................: 2.270182e-08
Hosmer and Lemeshow r^2...: 0.078722
Cox and Snell r^2.........: 0.085465
Nagelkerke's pseudo r^2...: 0.125955
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LAPTM5 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LAPTM5
Trait/outcome.............: IPH
Effect size...............: 0.01723
Standard error............: 0.031805
Odds ratio (effect size)..: 1.017
Lower 95% CI..............: 0.956
Upper 95% CI..............: 1.083
Z-value...................: 0.541755
P-value...................: 0.5879876
Hosmer and Lemeshow r^2...: 0.032842
Cox and Snell r^2.........: 0.043143
Nagelkerke's pseudo r^2...: 0.058388
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LAPTM5 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LAPTM5
Trait/outcome.............: MAC_binned
Effect size...............: 0.110583
Standard error............: 0.031751
Odds ratio (effect size)..: 1.117
Lower 95% CI..............: 1.05
Upper 95% CI..............: 1.189
Z-value...................: 3.4828
P-value...................: 0.0004961987
Hosmer and Lemeshow r^2...: 0.032958
Cox and Snell r^2.........: 0.044207
Nagelkerke's pseudo r^2...: 0.05923
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LAPTM5 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LAPTM5
Trait/outcome.............: SMC_binned
Effect size...............: -0.053214
Standard error............: 0.032846
Odds ratio (effect size)..: 0.948
Lower 95% CI..............: 0.889
Upper 95% CI..............: 1.011
Z-value...................: -1.620118
P-value...................: 0.105207
Hosmer and Lemeshow r^2...: 0.021227
Cox and Snell r^2.........: 0.02664
Nagelkerke's pseudo r^2...: 0.037014
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of MMP9.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' MMP9 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: MMP9
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.074887
Standard error............: 0.034174
Odds ratio (effect size)..: 0.928
Lower 95% CI..............: 0.868
Upper 95% CI..............: 0.992
Z-value...................: -2.191376
P-value...................: 0.02842458
Hosmer and Lemeshow r^2...: 0.093287
Cox and Snell r^2.........: 0.121194
Nagelkerke's pseudo r^2...: 0.161668
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' MMP9 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: MMP9
Trait/outcome.............: CollagenPlaque
Effect size...............: -0.016965
Standard error............: 0.039876
Odds ratio (effect size)..: 0.983
Lower 95% CI..............: 0.909
Upper 95% CI..............: 1.063
Z-value...................: -0.425455
P-value...................: 0.6705048
Hosmer and Lemeshow r^2...: 0.0048
Cox and Snell r^2.........: 0.004871
Nagelkerke's pseudo r^2...: 0.00763
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' MMP9 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: MMP9
Trait/outcome.............: Fat10Perc
Effect size...............: 0.244548
Standard error............: 0.042114
Odds ratio (effect size)..: 1.277
Lower 95% CI..............: 1.176
Upper 95% CI..............: 1.387
Z-value...................: 5.806753
P-value...................: 6.369591e-09
Hosmer and Lemeshow r^2...: 0.082447
Cox and Snell r^2.........: 0.089323
Nagelkerke's pseudo r^2...: 0.131641
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' MMP9 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: MMP9
Trait/outcome.............: IPH
Effect size...............: 0.010868
Standard error............: 0.033661
Odds ratio (effect size)..: 1.011
Lower 95% CI..............: 0.946
Upper 95% CI..............: 1.08
Z-value...................: 0.322858
P-value...................: 0.7468028
Hosmer and Lemeshow r^2...: 0.032691
Cox and Snell r^2.........: 0.042949
Nagelkerke's pseudo r^2...: 0.058126
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' MMP9 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: MMP9
Trait/outcome.............: MAC_binned
Effect size...............: 0.134466
Standard error............: 0.034053
Odds ratio (effect size)..: 1.144
Lower 95% CI..............: 1.07
Upper 95% CI..............: 1.223
Z-value...................: 3.948783
P-value...................: 7.85496e-05
Hosmer and Lemeshow r^2...: 0.035854
Cox and Snell r^2.........: 0.047997
Nagelkerke's pseudo r^2...: 0.064308
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' MMP9 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: MMP9
Trait/outcome.............: SMC_binned
Effect size...............: -0.089603
Standard error............: 0.034624
Odds ratio (effect size)..: 0.914
Lower 95% CI..............: 0.854
Upper 95% CI..............: 0.978
Z-value...................: -2.587914
P-value...................: 0.009655895
Hosmer and Lemeshow r^2...: 0.024674
Cox and Snell r^2.........: 0.030899
Nagelkerke's pseudo r^2...: 0.042931
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of SIGLEC1.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SIGLEC1 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SIGLEC1
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.050993
Standard error............: 0.037868
Odds ratio (effect size)..: 0.95
Lower 95% CI..............: 0.882
Upper 95% CI..............: 1.023
Z-value...................: -1.3466
P-value...................: 0.1781089
Hosmer and Lemeshow r^2...: 0.091019
Cox and Snell r^2.........: 0.118429
Nagelkerke's pseudo r^2...: 0.15798
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SIGLEC1 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SIGLEC1
Trait/outcome.............: CollagenPlaque
Effect size...............: -0.013743
Standard error............: 0.044572
Odds ratio (effect size)..: 0.986
Lower 95% CI..............: 0.904
Upper 95% CI..............: 1.076
Z-value...................: -0.308335
P-value...................: 0.7578273
Hosmer and Lemeshow r^2...: 0.00471
Cox and Snell r^2.........: 0.00478
Nagelkerke's pseudo r^2...: 0.007487
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SIGLEC1 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SIGLEC1
Trait/outcome.............: Fat10Perc
Effect size...............: 0.23782
Standard error............: 0.045461
Odds ratio (effect size)..: 1.268
Lower 95% CI..............: 1.16
Upper 95% CI..............: 1.387
Z-value...................: 5.231354
P-value...................: 1.682727e-07
Hosmer and Lemeshow r^2...: 0.075136
Cox and Snell r^2.........: 0.081736
Nagelkerke's pseudo r^2...: 0.120459
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SIGLEC1 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SIGLEC1
Trait/outcome.............: IPH
Effect size...............: 0.034127
Standard error............: 0.037684
Odds ratio (effect size)..: 1.035
Lower 95% CI..............: 0.961
Upper 95% CI..............: 1.114
Z-value...................: 0.905632
P-value...................: 0.3651307
Hosmer and Lemeshow r^2...: 0.033263
Cox and Snell r^2.........: 0.043684
Nagelkerke's pseudo r^2...: 0.059121
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SIGLEC1 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SIGLEC1
Trait/outcome.............: MAC_binned
Effect size...............: 0.115673
Standard error............: 0.037479
Odds ratio (effect size)..: 1.123
Lower 95% CI..............: 1.043
Upper 95% CI..............: 1.208
Z-value...................: 3.08637
P-value...................: 0.002026167
Hosmer and Lemeshow r^2...: 0.030873
Cox and Snell r^2.........: 0.041469
Nagelkerke's pseudo r^2...: 0.055561
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SIGLEC1 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SIGLEC1
Trait/outcome.............: SMC_binned
Effect size...............: -0.083676
Standard error............: 0.038642
Odds ratio (effect size)..: 0.92
Lower 95% CI..............: 0.853
Upper 95% CI..............: 0.992
Z-value...................: -2.165397
P-value...................: 0.03035727
Hosmer and Lemeshow r^2...: 0.02298
Cox and Snell r^2.........: 0.028808
Nagelkerke's pseudo r^2...: 0.040026
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of FTL.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FTL ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FTL
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.059386
Standard error............: 0.03214
Odds ratio (effect size)..: 0.942
Lower 95% CI..............: 0.885
Upper 95% CI..............: 1.004
Z-value...................: -1.847736
P-value...................: 0.0646406
Hosmer and Lemeshow r^2...: 0.092234
Cox and Snell r^2.........: 0.119912
Nagelkerke's pseudo r^2...: 0.159958
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FTL ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FTL
Trait/outcome.............: CollagenPlaque
Effect size...............: 0.015922
Standard error............: 0.037982
Odds ratio (effect size)..: 1.016
Lower 95% CI..............: 0.943
Upper 95% CI..............: 1.095
Z-value...................: 0.419201
P-value...................: 0.6750691
Hosmer and Lemeshow r^2...: 0.004795
Cox and Snell r^2.........: 0.004865
Nagelkerke's pseudo r^2...: 0.007621
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FTL ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FTL
Trait/outcome.............: Fat10Perc
Effect size...............: 0.164925
Standard error............: 0.035998
Odds ratio (effect size)..: 1.179
Lower 95% CI..............: 1.099
Upper 95% CI..............: 1.266
Z-value...................: 4.581471
P-value...................: 4.617172e-06
Hosmer and Lemeshow r^2...: 0.067938
Cox and Snell r^2.........: 0.074204
Nagelkerke's pseudo r^2...: 0.109358
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FTL ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FTL
Trait/outcome.............: IPH
Effect size...............: 0.011028
Standard error............: 0.031862
Odds ratio (effect size)..: 1.011
Lower 95% CI..............: 0.95
Upper 95% CI..............: 1.076
Z-value...................: 0.346117
P-value...................: 0.7292548
Hosmer and Lemeshow r^2...: 0.032703
Cox and Snell r^2.........: 0.042965
Nagelkerke's pseudo r^2...: 0.058147
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FTL ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FTL
Trait/outcome.............: MAC_binned
Effect size...............: 0.095075
Standard error............: 0.031584
Odds ratio (effect size)..: 1.1
Lower 95% CI..............: 1.034
Upper 95% CI..............: 1.17
Z-value...................: 3.0102
P-value...................: 0.002610757
Hosmer and Lemeshow r^2...: 0.030474
Cox and Snell r^2.........: 0.040944
Nagelkerke's pseudo r^2...: 0.054858
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' FTL ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: FTL
Trait/outcome.............: SMC_binned
Effect size...............: -0.054511
Standard error............: 0.033319
Odds ratio (effect size)..: 0.947
Lower 95% CI..............: 0.887
Upper 95% CI..............: 1.011
Z-value...................: -1.636036
P-value...................: 0.101832
Hosmer and Lemeshow r^2...: 0.021287
Cox and Snell r^2.........: 0.026715
Nagelkerke's pseudo r^2...: 0.037117
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of CD14.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CD14 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CD14
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.057083
Standard error............: 0.032607
Odds ratio (effect size)..: 0.945
Lower 95% CI..............: 0.886
Upper 95% CI..............: 1.007
Z-value...................: -1.750626
P-value...................: 0.08001042
Hosmer and Lemeshow r^2...: 0.091967
Cox and Snell r^2.........: 0.119586
Nagelkerke's pseudo r^2...: 0.159523
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CD14 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CD14
Trait/outcome.............: CollagenPlaque
Effect size...............: 0.002244
Standard error............: 0.038493
Odds ratio (effect size)..: 1.002
Lower 95% CI..............: 0.929
Upper 95% CI..............: 1.081
Z-value...................: 0.058307
P-value...................: 0.9535039
Hosmer and Lemeshow r^2...: 0.004613
Cox and Snell r^2.........: 0.004682
Nagelkerke's pseudo r^2...: 0.007334
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CD14 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CD14
Trait/outcome.............: Fat10Perc
Effect size...............: 0.207223
Standard error............: 0.038164
Odds ratio (effect size)..: 1.23
Lower 95% CI..............: 1.142
Upper 95% CI..............: 1.326
Z-value...................: 5.429805
P-value...................: 5.64158e-08
Hosmer and Lemeshow r^2...: 0.076876
Cox and Snell r^2.........: 0.083548
Nagelkerke's pseudo r^2...: 0.123129
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CD14 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CD14
Trait/outcome.............: IPH
Effect size...............: 0.022195
Standard error............: 0.032308
Odds ratio (effect size)..: 1.022
Lower 95% CI..............: 0.96
Upper 95% CI..............: 1.089
Z-value...................: 0.686966
P-value...................: 0.4921043
Hosmer and Lemeshow r^2...: 0.032984
Cox and Snell r^2.........: 0.043326
Nagelkerke's pseudo r^2...: 0.058636
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CD14 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CD14
Trait/outcome.............: MAC_binned
Effect size...............: 0.105765
Standard error............: 0.032199
Odds ratio (effect size)..: 1.112
Lower 95% CI..............: 1.044
Upper 95% CI..............: 1.184
Z-value...................: 3.28468
P-value...................: 0.001020981
Hosmer and Lemeshow r^2...: 0.031879
Cox and Snell r^2.........: 0.042791
Nagelkerke's pseudo r^2...: 0.057332
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CD14 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CD14
Trait/outcome.............: SMC_binned
Effect size...............: -0.053002
Standard error............: 0.033335
Odds ratio (effect size)..: 0.948
Lower 95% CI..............: 0.888
Upper 95% CI..............: 1.012
Z-value...................: -1.589957
P-value...................: 0.1118446
Hosmer and Lemeshow r^2...: 0.021145
Cox and Snell r^2.........: 0.026538
Nagelkerke's pseudo r^2...: 0.036872
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of HCST.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' HCST ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: HCST
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.066796
Standard error............: 0.033195
Odds ratio (effect size)..: 0.935
Lower 95% CI..............: 0.876
Upper 95% CI..............: 0.998
Z-value...................: -2.012232
P-value...................: 0.04419547
Hosmer and Lemeshow r^2...: 0.092713
Cox and Snell r^2.........: 0.120495
Nagelkerke's pseudo r^2...: 0.160736
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' HCST ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: HCST
Trait/outcome.............: CollagenPlaque
Effect size...............: 0.010488
Standard error............: 0.039191
Odds ratio (effect size)..: 1.011
Lower 95% CI..............: 0.936
Upper 95% CI..............: 1.091
Z-value...................: 0.267599
P-value...................: 0.7890083
Hosmer and Lemeshow r^2...: 0.004685
Cox and Snell r^2.........: 0.004755
Nagelkerke's pseudo r^2...: 0.007448
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' HCST ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: HCST
Trait/outcome.............: Fat10Perc
Effect size...............: 0.178208
Standard error............: 0.038182
Odds ratio (effect size)..: 1.195
Lower 95% CI..............: 1.109
Upper 95% CI..............: 1.288
Z-value...................: 4.667274
P-value...................: 3.052224e-06
Hosmer and Lemeshow r^2...: 0.069083
Cox and Snell r^2.........: 0.075406
Nagelkerke's pseudo r^2...: 0.11113
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' HCST ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: HCST
Trait/outcome.............: IPH
Effect size...............: 0.009391
Standard error............: 0.032858
Odds ratio (effect size)..: 1.009
Lower 95% CI..............: 0.946
Upper 95% CI..............: 1.077
Z-value...................: 0.285801
P-value...................: 0.7750307
Hosmer and Lemeshow r^2...: 0.032673
Cox and Snell r^2.........: 0.042926
Nagelkerke's pseudo r^2...: 0.058094
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' HCST ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: HCST
Trait/outcome.............: MAC_binned
Effect size...............: 0.112807
Standard error............: 0.032784
Odds ratio (effect size)..: 1.119
Lower 95% CI..............: 1.05
Upper 95% CI..............: 1.194
Z-value...................: 3.440886
P-value...................: 0.0005798135
Hosmer and Lemeshow r^2...: 0.032727
Cox and Snell r^2.........: 0.043904
Nagelkerke's pseudo r^2...: 0.058823
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' HCST ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: HCST
Trait/outcome.............: SMC_binned
Effect size...............: -0.042191
Standard error............: 0.033948
Odds ratio (effect size)..: 0.959
Lower 95% CI..............: 0.897
Upper 95% CI..............: 1.025
Z-value...................: -1.242818
P-value...................: 0.2139351
Hosmer and Lemeshow r^2...: 0.020308
Cox and Snell r^2.........: 0.025501
Nagelkerke's pseudo r^2...: 0.035431
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of TIMP3.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TIMP3 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TIMP3
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.006759
Standard error............: 0.037133
Odds ratio (effect size)..: 0.993
Lower 95% CI..............: 0.924
Upper 95% CI..............: 1.068
Z-value...................: -0.182011
P-value...................: 0.8555738
Hosmer and Lemeshow r^2...: 0.089675
Cox and Snell r^2.........: 0.116788
Nagelkerke's pseudo r^2...: 0.15579
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TIMP3 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TIMP3
Trait/outcome.............: CollagenPlaque
Effect size...............: -0.014044
Standard error............: 0.043757
Odds ratio (effect size)..: 0.986
Lower 95% CI..............: 0.905
Upper 95% CI..............: 1.074
Z-value...................: -0.320957
P-value...................: 0.7482432
Hosmer and Lemeshow r^2...: 0.004718
Cox and Snell r^2.........: 0.004788
Nagelkerke's pseudo r^2...: 0.0075
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TIMP3 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TIMP3
Trait/outcome.............: Fat10Perc
Effect size...............: 0.188531
Standard error............: 0.043786
Odds ratio (effect size)..: 1.207
Lower 95% CI..............: 1.108
Upper 95% CI..............: 1.316
Z-value...................: 4.305789
P-value...................: 1.663918e-05
Hosmer and Lemeshow r^2...: 0.066255
Cox and Snell r^2.........: 0.072433
Nagelkerke's pseudo r^2...: 0.106749
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TIMP3 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TIMP3
Trait/outcome.............: IPH
Effect size...............: 0.054645
Standard error............: 0.037179
Odds ratio (effect size)..: 1.056
Lower 95% CI..............: 0.982
Upper 95% CI..............: 1.136
Z-value...................: 1.46978
P-value...................: 0.1416213
Hosmer and Lemeshow r^2...: 0.034342
Cox and Snell r^2.........: 0.045068
Nagelkerke's pseudo r^2...: 0.060994
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TIMP3 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TIMP3
Trait/outcome.............: MAC_binned
Effect size...............: 0.115963
Standard error............: 0.037101
Odds ratio (effect size)..: 1.123
Lower 95% CI..............: 1.044
Upper 95% CI..............: 1.208
Z-value...................: 3.125601
P-value...................: 0.001774423
Hosmer and Lemeshow r^2...: 0.031103
Cox and Snell r^2.........: 0.041771
Nagelkerke's pseudo r^2...: 0.055966
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TIMP3 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TIMP3
Trait/outcome.............: SMC_binned
Effect size...............: -0.091839
Standard error............: 0.037844
Odds ratio (effect size)..: 0.912
Lower 95% CI..............: 0.847
Upper 95% CI..............: 0.982
Z-value...................: -2.426761
P-value...................: 0.01523429
Hosmer and Lemeshow r^2...: 0.023997
Cox and Snell r^2.........: 0.030064
Nagelkerke's pseudo r^2...: 0.041771
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of CCL2.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CCL2 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CCL2
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.048556
Standard error............: 0.039603
Odds ratio (effect size)..: 0.953
Lower 95% CI..............: 0.881
Upper 95% CI..............: 1.029
Z-value...................: -1.226075
P-value...................: 0.2201705
Hosmer and Lemeshow r^2...: 0.090785
Cox and Snell r^2.........: 0.118144
Nagelkerke's pseudo r^2...: 0.1576
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CCL2 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CCL2
Trait/outcome.............: CollagenPlaque
Effect size...............: -0.018857
Standard error............: 0.046716
Odds ratio (effect size)..: 0.981
Lower 95% CI..............: 0.895
Upper 95% CI..............: 1.075
Z-value...................: -0.403662
P-value...................: 0.6864612
Hosmer and Lemeshow r^2...: 0.004781
Cox and Snell r^2.........: 0.004852
Nagelkerke's pseudo r^2...: 0.0076
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CCL2 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CCL2
Trait/outcome.............: Fat10Perc
Effect size...............: 0.223825
Standard error............: 0.046291
Odds ratio (effect size)..: 1.251
Lower 95% CI..............: 1.142
Upper 95% CI..............: 1.37
Z-value...................: 4.83514
P-value...................: 1.33052e-06
Hosmer and Lemeshow r^2...: 0.070915
Cox and Snell r^2.........: 0.077326
Nagelkerke's pseudo r^2...: 0.11396
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CCL2 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CCL2
Trait/outcome.............: IPH
Effect size...............: 0.043925
Standard error............: 0.039304
Odds ratio (effect size)..: 1.045
Lower 95% CI..............: 0.967
Upper 95% CI..............: 1.129
Z-value...................: 1.117558
P-value...................: 0.2637557
Hosmer and Lemeshow r^2...: 0.033606
Cox and Snell r^2.........: 0.044125
Nagelkerke's pseudo r^2...: 0.059717
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CCL2 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CCL2
Trait/outcome.............: MAC_binned
Effect size...............: 0.061223
Standard error............: 0.038754
Odds ratio (effect size)..: 1.063
Lower 95% CI..............: 0.985
Upper 95% CI..............: 1.147
Z-value...................: 1.579804
P-value...................: 0.1141517
Hosmer and Lemeshow r^2...: 0.025234
Cox and Snell r^2.........: 0.034025
Nagelkerke's pseudo r^2...: 0.045588
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CCL2 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CCL2
Trait/outcome.............: SMC_binned
Effect size...............: -0.073586
Standard error............: 0.040586
Odds ratio (effect size)..: 0.929
Lower 95% CI..............: 0.858
Upper 95% CI..............: 1.006
Z-value...................: -1.813109
P-value...................: 0.06981495
Hosmer and Lemeshow r^2...: 0.021789
Cox and Snell r^2.........: 0.027336
Nagelkerke's pseudo r^2...: 0.037981
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of SAT1.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SAT1 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SAT1
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.053925
Standard error............: 0.03366
Odds ratio (effect size)..: 0.948
Lower 95% CI..............: 0.887
Upper 95% CI..............: 1.012
Z-value...................: -1.602052
P-value...................: 0.1091442
Hosmer and Lemeshow r^2...: 0.091589
Cox and Snell r^2.........: 0.119125
Nagelkerke's pseudo r^2...: 0.158909
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SAT1 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SAT1
Trait/outcome.............: CollagenPlaque
Effect size...............: 0.003459
Standard error............: 0.039946
Odds ratio (effect size)..: 1.003
Lower 95% CI..............: 0.928
Upper 95% CI..............: 1.085
Z-value...................: 0.086592
P-value...................: 0.930996
Hosmer and Lemeshow r^2...: 0.004618
Cox and Snell r^2.........: 0.004686
Nagelkerke's pseudo r^2...: 0.007341
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SAT1 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SAT1
Trait/outcome.............: Fat10Perc
Effect size...............: 0.181957
Standard error............: 0.039173
Odds ratio (effect size)..: 1.2
Lower 95% CI..............: 1.111
Upper 95% CI..............: 1.295
Z-value...................: 4.644933
P-value...................: 3.401873e-06
Hosmer and Lemeshow r^2...: 0.068922
Cox and Snell r^2.........: 0.075237
Nagelkerke's pseudo r^2...: 0.110882
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SAT1 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SAT1
Trait/outcome.............: IPH
Effect size...............: 0.028265
Standard error............: 0.033486
Odds ratio (effect size)..: 1.029
Lower 95% CI..............: 0.963
Upper 95% CI..............: 1.098
Z-value...................: 0.844072
P-value...................: 0.3986291
Hosmer and Lemeshow r^2...: 0.033176
Cox and Snell r^2.........: 0.043573
Nagelkerke's pseudo r^2...: 0.05897
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SAT1 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SAT1
Trait/outcome.............: MAC_binned
Effect size...............: 0.098454
Standard error............: 0.033227
Odds ratio (effect size)..: 1.103
Lower 95% CI..............: 1.034
Upper 95% CI..............: 1.178
Z-value...................: 2.963033
P-value...................: 0.00304624
Hosmer and Lemeshow r^2...: 0.030257
Cox and Snell r^2.........: 0.040659
Nagelkerke's pseudo r^2...: 0.054476
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' SAT1 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: SAT1
Trait/outcome.............: SMC_binned
Effect size...............: -0.077845
Standard error............: 0.034741
Odds ratio (effect size)..: 0.925
Lower 95% CI..............: 0.864
Upper 95% CI..............: 0.99
Z-value...................: -2.240755
P-value...................: 0.02504193
Hosmer and Lemeshow r^2...: 0.023282
Cox and Snell r^2.........: 0.029182
Nagelkerke's pseudo r^2...: 0.040545
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of CD163.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CD163 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CD163
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.070342
Standard error............: 0.050214
Odds ratio (effect size)..: 0.932
Lower 95% CI..............: 0.845
Upper 95% CI..............: 1.028
Z-value...................: -1.400832
P-value...................: 0.1612644
Hosmer and Lemeshow r^2...: 0.091135
Cox and Snell r^2.........: 0.118571
Nagelkerke's pseudo r^2...: 0.158169
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CD163 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CD163
Trait/outcome.............: CollagenPlaque
Effect size...............: -0.03519
Standard error............: 0.058405
Odds ratio (effect size)..: 0.965
Lower 95% CI..............: 0.861
Upper 95% CI..............: 1.083
Z-value...................: -0.602517
P-value...................: 0.5468298
Hosmer and Lemeshow r^2...: 0.004991
Cox and Snell r^2.........: 0.005064
Nagelkerke's pseudo r^2...: 0.007933
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CD163 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CD163
Trait/outcome.............: Fat10Perc
Effect size...............: 0.351385
Standard error............: 0.061804
Odds ratio (effect size)..: 1.421
Lower 95% CI..............: 1.259
Upper 95% CI..............: 1.604
Z-value...................: 5.685512
P-value...................: 1.304212e-08
Hosmer and Lemeshow r^2...: 0.081174
Cox and Snell r^2.........: 0.088007
Nagelkerke's pseudo r^2...: 0.1297
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CD163 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CD163
Trait/outcome.............: IPH
Effect size...............: 0.077476
Standard error............: 0.049826
Odds ratio (effect size)..: 1.081
Lower 95% CI..............: 0.98
Upper 95% CI..............: 1.191
Z-value...................: 1.554923
P-value...................: 0.1199644
Hosmer and Lemeshow r^2...: 0.03455
Cox and Snell r^2.........: 0.045335
Nagelkerke's pseudo r^2...: 0.061355
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CD163 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CD163
Trait/outcome.............: MAC_binned
Effect size...............: 0.166326
Standard error............: 0.04992
Odds ratio (effect size)..: 1.181
Lower 95% CI..............: 1.071
Upper 95% CI..............: 1.302
Z-value...................: 3.331875
P-value...................: 0.0008626285
Hosmer and Lemeshow r^2...: 0.0322
Cox and Snell r^2.........: 0.043212
Nagelkerke's pseudo r^2...: 0.057897
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' CD163 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: CD163
Trait/outcome.............: SMC_binned
Effect size...............: -0.085158
Standard error............: 0.050582
Odds ratio (effect size)..: 0.918
Lower 95% CI..............: 0.832
Upper 95% CI..............: 1.014
Z-value...................: -1.683577
P-value...................: 0.09226347
Hosmer and Lemeshow r^2...: 0.021396
Cox and Snell r^2.........: 0.026849
Nagelkerke's pseudo r^2...: 0.037303
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of PTGDS.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' PTGDS ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: PTGDS
Trait/outcome.............: CalcificationPlaque
Effect size...............: 0.001175
Standard error............: 0.043781
Odds ratio (effect size)..: 1.001
Lower 95% CI..............: 0.919
Upper 95% CI..............: 1.091
Z-value...................: 0.026838
P-value...................: 0.9785891
Hosmer and Lemeshow r^2...: 0.089651
Cox and Snell r^2.........: 0.116758
Nagelkerke's pseudo r^2...: 0.155751
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' PTGDS ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: PTGDS
Trait/outcome.............: CollagenPlaque
Effect size...............: 0.024449
Standard error............: 0.052344
Odds ratio (effect size)..: 1.025
Lower 95% CI..............: 0.925
Upper 95% CI..............: 1.135
Z-value...................: 0.467088
P-value...................: 0.640437
Hosmer and Lemeshow r^2...: 0.004841
Cox and Snell r^2.........: 0.004913
Nagelkerke's pseudo r^2...: 0.007695
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' PTGDS ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: PTGDS
Trait/outcome.............: Fat10Perc
Effect size...............: 0.232826
Standard error............: 0.054775
Odds ratio (effect size)..: 1.262
Lower 95% CI..............: 1.134
Upper 95% CI..............: 1.405
Z-value...................: 4.250624
P-value...................: 2.131758e-05
Hosmer and Lemeshow r^2...: 0.066343
Cox and Snell r^2.........: 0.072526
Nagelkerke's pseudo r^2...: 0.106886
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' PTGDS ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: PTGDS
Trait/outcome.............: IPH
Effect size...............: 0.064694
Standard error............: 0.044296
Odds ratio (effect size)..: 1.067
Lower 95% CI..............: 0.978
Upper 95% CI..............: 1.164
Z-value...................: 1.460484
P-value...................: 0.1441572
Hosmer and Lemeshow r^2...: 0.034327
Cox and Snell r^2.........: 0.045049
Nagelkerke's pseudo r^2...: 0.060968
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' PTGDS ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: PTGDS
Trait/outcome.............: MAC_binned
Effect size...............: 0.155392
Standard error............: 0.044489
Odds ratio (effect size)..: 1.168
Lower 95% CI..............: 1.071
Upper 95% CI..............: 1.275
Z-value...................: 3.492857
P-value...................: 0.0004778821
Hosmer and Lemeshow r^2...: 0.033196
Cox and Snell r^2.........: 0.044519
Nagelkerke's pseudo r^2...: 0.059647
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' PTGDS ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: PTGDS
Trait/outcome.............: SMC_binned
Effect size...............: -0.071357
Standard error............: 0.044228
Odds ratio (effect size)..: 0.931
Lower 95% CI..............: 0.854
Upper 95% CI..............: 1.015
Z-value...................: -1.613379
P-value...................: 0.1066623
Hosmer and Lemeshow r^2...: 0.021192
Cox and Snell r^2.........: 0.026597
Nagelkerke's pseudo r^2...: 0.036954
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of LGALS9.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LGALS9 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LGALS9
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.080316
Standard error............: 0.040005
Odds ratio (effect size)..: 0.923
Lower 95% CI..............: 0.853
Upper 95% CI..............: 0.998
Z-value...................: -2.007627
P-value...................: 0.04468291
Hosmer and Lemeshow r^2...: 0.0927
Cox and Snell r^2.........: 0.120479
Nagelkerke's pseudo r^2...: 0.160715
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LGALS9 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LGALS9
Trait/outcome.............: CollagenPlaque
Effect size...............: -0.004658
Standard error............: 0.04711
Odds ratio (effect size)..: 0.995
Lower 95% CI..............: 0.908
Upper 95% CI..............: 1.092
Z-value...................: -0.098866
P-value...................: 0.921245
Hosmer and Lemeshow r^2...: 0.00462
Cox and Snell r^2.........: 0.004689
Nagelkerke's pseudo r^2...: 0.007344
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LGALS9 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LGALS9
Trait/outcome.............: Fat10Perc
Effect size...............: 0.258815
Standard error............: 0.048379
Odds ratio (effect size)..: 1.295
Lower 95% CI..............: 1.178
Upper 95% CI..............: 1.424
Z-value...................: 5.349708
P-value...................: 8.809647e-08
Hosmer and Lemeshow r^2...: 0.0766
Cox and Snell r^2.........: 0.08326
Nagelkerke's pseudo r^2...: 0.122705
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LGALS9 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LGALS9
Trait/outcome.............: IPH
Effect size...............: 0.029401
Standard error............: 0.039648
Odds ratio (effect size)..: 1.03
Lower 95% CI..............: 0.953
Upper 95% CI..............: 1.113
Z-value...................: 0.74157
P-value...................: 0.4583476
Hosmer and Lemeshow r^2...: 0.033047
Cox and Snell r^2.........: 0.043407
Nagelkerke's pseudo r^2...: 0.058745
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LGALS9 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LGALS9
Trait/outcome.............: MAC_binned
Effect size...............: 0.147841
Standard error............: 0.039716
Odds ratio (effect size)..: 1.159
Lower 95% CI..............: 1.073
Upper 95% CI..............: 1.253
Z-value...................: 3.722449
P-value...................: 0.0001973
Hosmer and Lemeshow r^2...: 0.034407
Cox and Snell r^2.........: 0.046105
Nagelkerke's pseudo r^2...: 0.061773
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' LGALS9 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: LGALS9
Trait/outcome.............: SMC_binned
Effect size...............: -0.071606
Standard error............: 0.040673
Odds ratio (effect size)..: 0.931
Lower 95% CI..............: 0.86
Upper 95% CI..............: 1.008
Z-value...................: -1.760506
P-value...................: 0.07832213
Hosmer and Lemeshow r^2...: 0.021624
Cox and Snell r^2.........: 0.027131
Nagelkerke's pseudo r^2...: 0.037696
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of ACKR1.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ACKR1 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ACKR1
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.028424
Standard error............: 0.047369
Odds ratio (effect size)..: 0.972
Lower 95% CI..............: 0.886
Upper 95% CI..............: 1.067
Z-value...................: -0.600049
P-value...................: 0.5484737
Hosmer and Lemeshow r^2...: 0.089922
Cox and Snell r^2.........: 0.117089
Nagelkerke's pseudo r^2...: 0.156192
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ACKR1 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ACKR1
Trait/outcome.............: CollagenPlaque
Effect size...............: 0.036127
Standard error............: 0.057121
Odds ratio (effect size)..: 1.037
Lower 95% CI..............: 0.927
Upper 95% CI..............: 1.16
Z-value...................: 0.632469
P-value...................: 0.5270804
Hosmer and Lemeshow r^2...: 0.005036
Cox and Snell r^2.........: 0.00511
Nagelkerke's pseudo r^2...: 0.008004
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ACKR1 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ACKR1
Trait/outcome.............: Fat10Perc
Effect size...............: 0.240094
Standard error............: 0.059472
Odds ratio (effect size)..: 1.271
Lower 95% CI..............: 1.131
Upper 95% CI..............: 1.429
Z-value...................: 4.037113
P-value...................: 5.411301e-05
Hosmer and Lemeshow r^2...: 0.064606
Cox and Snell r^2.........: 0.070697
Nagelkerke's pseudo r^2...: 0.10419
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ACKR1 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ACKR1
Trait/outcome.............: IPH
Effect size...............: 0.124773
Standard error............: 0.048924
Odds ratio (effect size)..: 1.133
Lower 95% CI..............: 1.029
Upper 95% CI..............: 1.247
Z-value...................: 2.550336
P-value...................: 0.01076191
Hosmer and Lemeshow r^2...: 0.037934
Cox and Snell r^2.........: 0.049663
Nagelkerke's pseudo r^2...: 0.067212
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ACKR1 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ACKR1
Trait/outcome.............: MAC_binned
Effect size...............: 0.15374
Standard error............: 0.048184
Odds ratio (effect size)..: 1.166
Lower 95% CI..............: 1.061
Upper 95% CI..............: 1.282
Z-value...................: 3.190681
P-value...................: 0.001419379
Hosmer and Lemeshow r^2...: 0.031532
Cox and Snell r^2.........: 0.042336
Nagelkerke's pseudo r^2...: 0.056723
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' ACKR1 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: ACKR1
Trait/outcome.............: SMC_binned
Effect size...............: -0.110602
Standard error............: 0.048095
Odds ratio (effect size)..: 0.895
Lower 95% CI..............: 0.815
Upper 95% CI..............: 0.984
Z-value...................: -2.29968
P-value...................: 0.02146633
Hosmer and Lemeshow r^2...: 0.02345
Cox and Snell r^2.........: 0.029388
Nagelkerke's pseudo r^2...: 0.040832
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of NT5DC2.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' NT5DC2 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: NT5DC2
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.079257
Standard error............: 0.043824
Odds ratio (effect size)..: 0.924
Lower 95% CI..............: 0.848
Upper 95% CI..............: 1.007
Z-value...................: -1.808535
P-value...................: 0.07052335
Hosmer and Lemeshow r^2...: 0.092121
Cox and Snell r^2.........: 0.119775
Nagelkerke's pseudo r^2...: 0.159775
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' NT5DC2 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: NT5DC2
Trait/outcome.............: CollagenPlaque
Effect size...............: -0.001012
Standard error............: 0.051805
Odds ratio (effect size)..: 0.999
Lower 95% CI..............: 0.903
Upper 95% CI..............: 1.106
Z-value...................: -0.019535
P-value...................: 0.9844146
Hosmer and Lemeshow r^2...: 0.00461
Cox and Snell r^2.........: 0.004679
Nagelkerke's pseudo r^2...: 0.007329
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' NT5DC2 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: NT5DC2
Trait/outcome.............: Fat10Perc
Effect size...............: 0.217611
Standard error............: 0.050575
Odds ratio (effect size)..: 1.243
Lower 95% CI..............: 1.126
Upper 95% CI..............: 1.373
Z-value...................: 4.30275
P-value...................: 1.686913e-05
Hosmer and Lemeshow r^2...: 0.065972
Cox and Snell r^2.........: 0.072136
Nagelkerke's pseudo r^2...: 0.106311
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' NT5DC2 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: NT5DC2
Trait/outcome.............: IPH
Effect size...............: 0.066239
Standard error............: 0.043823
Odds ratio (effect size)..: 1.068
Lower 95% CI..............: 0.981
Upper 95% CI..............: 1.164
Z-value...................: 1.511511
P-value...................: 0.1306584
Hosmer and Lemeshow r^2...: 0.034438
Cox and Snell r^2.........: 0.045192
Nagelkerke's pseudo r^2...: 0.061162
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' NT5DC2 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: NT5DC2
Trait/outcome.............: MAC_binned
Effect size...............: 0.098625
Standard error............: 0.043375
Odds ratio (effect size)..: 1.104
Lower 95% CI..............: 1.014
Upper 95% CI..............: 1.202
Z-value...................: 2.273797
P-value...................: 0.02297821
Hosmer and Lemeshow r^2...: 0.027369
Cox and Snell r^2.........: 0.03685
Nagelkerke's pseudo r^2...: 0.049373
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' NT5DC2 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: NT5DC2
Trait/outcome.............: SMC_binned
Effect size...............: -0.072896
Standard error............: 0.0449
Odds ratio (effect size)..: 0.93
Lower 95% CI..............: 0.851
Upper 95% CI..............: 1.015
Z-value...................: -1.623531
P-value...................: 0.1044759
Hosmer and Lemeshow r^2...: 0.021235
Cox and Snell r^2.........: 0.02665
Nagelkerke's pseudo r^2...: 0.037028
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of TGFBI.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TGFBI ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TGFBI
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.046886
Standard error............: 0.039591
Odds ratio (effect size)..: 0.954
Lower 95% CI..............: 0.883
Upper 95% CI..............: 1.031
Z-value...................: -1.184264
P-value...................: 0.2363087
Hosmer and Lemeshow r^2...: 0.090708
Cox and Snell r^2.........: 0.11805
Nagelkerke's pseudo r^2...: 0.157475
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TGFBI ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TGFBI
Trait/outcome.............: CollagenPlaque
Effect size...............: 0.006278
Standard error............: 0.046823
Odds ratio (effect size)..: 1.006
Lower 95% CI..............: 0.918
Upper 95% CI..............: 1.103
Z-value...................: 0.134081
P-value...................: 0.8933385
Hosmer and Lemeshow r^2...: 0.004629
Cox and Snell r^2.........: 0.004697
Nagelkerke's pseudo r^2...: 0.007358
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TGFBI ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TGFBI
Trait/outcome.............: Fat10Perc
Effect size...............: 0.220852
Standard error............: 0.046335
Odds ratio (effect size)..: 1.247
Lower 95% CI..............: 1.139
Upper 95% CI..............: 1.366
Z-value...................: 4.766361
P-value...................: 1.875832e-06
Hosmer and Lemeshow r^2...: 0.070284
Cox and Snell r^2.........: 0.076666
Nagelkerke's pseudo r^2...: 0.112987
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TGFBI ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TGFBI
Trait/outcome.............: IPH
Effect size...............: 0.058406
Standard error............: 0.039456
Odds ratio (effect size)..: 1.06
Lower 95% CI..............: 0.981
Upper 95% CI..............: 1.145
Z-value...................: 1.480299
P-value...................: 0.1387935
Hosmer and Lemeshow r^2...: 0.034364
Cox and Snell r^2.........: 0.045096
Nagelkerke's pseudo r^2...: 0.061032
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TGFBI ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TGFBI
Trait/outcome.............: MAC_binned
Effect size...............: 0.103025
Standard error............: 0.039088
Odds ratio (effect size)..: 1.109
Lower 95% CI..............: 1.027
Upper 95% CI..............: 1.197
Z-value...................: 2.635706
P-value...................: 0.008396254
Hosmer and Lemeshow r^2...: 0.028794
Cox and Snell r^2.........: 0.038731
Nagelkerke's pseudo r^2...: 0.051893
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' TGFBI ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: TGFBI
Trait/outcome.............: SMC_binned
Effect size...............: -0.057712
Standard error............: 0.040451
Odds ratio (effect size)..: 0.944
Lower 95% CI..............: 0.872
Upper 95% CI..............: 1.022
Z-value...................: -1.426734
P-value...................: 0.1536565
Hosmer and Lemeshow r^2...: 0.020722
Cox and Snell r^2.........: 0.026015
Nagelkerke's pseudo r^2...: 0.036145
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of C1QC.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' C1QC ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: C1QC
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.056028
Standard error............: 0.036633
Odds ratio (effect size)..: 0.946
Lower 95% CI..............: 0.88
Upper 95% CI..............: 1.016
Z-value...................: -1.529436
P-value...................: 0.1261565
Hosmer and Lemeshow r^2...: 0.091415
Cox and Snell r^2.........: 0.118913
Nagelkerke's pseudo r^2...: 0.158626
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' C1QC ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: C1QC
Trait/outcome.............: CollagenPlaque
Effect size...............: 0.018597
Standard error............: 0.043323
Odds ratio (effect size)..: 1.019
Lower 95% CI..............: 0.936
Upper 95% CI..............: 1.109
Z-value...................: 0.42926
P-value...................: 0.6677338
Hosmer and Lemeshow r^2...: 0.004804
Cox and Snell r^2.........: 0.004875
Nagelkerke's pseudo r^2...: 0.007637
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' C1QC ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: C1QC
Trait/outcome.............: Fat10Perc
Effect size...............: 0.252761
Standard error............: 0.043927
Odds ratio (effect size)..: 1.288
Lower 95% CI..............: 1.181
Upper 95% CI..............: 1.403
Z-value...................: 5.754151
P-value...................: 8.707835e-09
Hosmer and Lemeshow r^2...: 0.080805
Cox and Snell r^2.........: 0.087625
Nagelkerke's pseudo r^2...: 0.129138
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' C1QC ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: C1QC
Trait/outcome.............: IPH
Effect size...............: 0.026789
Standard error............: 0.036426
Odds ratio (effect size)..: 1.027
Lower 95% CI..............: 0.956
Upper 95% CI..............: 1.103
Z-value...................: 0.735421
P-value...................: 0.4620831
Hosmer and Lemeshow r^2...: 0.03304
Cox and Snell r^2.........: 0.043397
Nagelkerke's pseudo r^2...: 0.058732
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' C1QC ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: C1QC
Trait/outcome.............: MAC_binned
Effect size...............: 0.131122
Standard error............: 0.036441
Odds ratio (effect size)..: 1.14
Lower 95% CI..............: 1.062
Upper 95% CI..............: 1.225
Z-value...................: 3.598226
P-value...................: 0.0003203952
Hosmer and Lemeshow r^2...: 0.033646
Cox and Snell r^2.........: 0.045109
Nagelkerke's pseudo r^2...: 0.060438
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' C1QC ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: C1QC
Trait/outcome.............: SMC_binned
Effect size...............: -0.064927
Standard error............: 0.03748
Odds ratio (effect size)..: 0.937
Lower 95% CI..............: 0.871
Upper 95% CI..............: 1.009
Z-value...................: -1.732302
P-value...................: 0.08321973
Hosmer and Lemeshow r^2...: 0.021546
Cox and Snell r^2.........: 0.027034
Nagelkerke's pseudo r^2...: 0.037562
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
Analysis of S100A9.
- processing CalcificationPlaque
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' S100A9 ' with ' CalcificationPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: S100A9
Trait/outcome.............: CalcificationPlaque
Effect size...............: -0.064164
Standard error............: 0.048512
Odds ratio (effect size)..: 0.938
Lower 95% CI..............: 0.853
Upper 95% CI..............: 1.031
Z-value...................: -1.322639
P-value...................: 0.1859556
Hosmer and Lemeshow r^2...: 0.090971
Cox and Snell r^2.........: 0.118371
Nagelkerke's pseudo r^2...: 0.157902
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing CollagenPlaque
filter: removed 160 rows (15%), 932 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' S100A9 ' with ' CollagenPlaque ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: S100A9
Trait/outcome.............: CollagenPlaque
Effect size...............: -0.03287
Standard error............: 0.056937
Odds ratio (effect size)..: 0.968
Lower 95% CI..............: 0.865
Upper 95% CI..............: 1.082
Z-value...................: -0.577303
P-value...................: 0.563735
Hosmer and Lemeshow r^2...: 0.00496
Cox and Snell r^2.........: 0.005033
Nagelkerke's pseudo r^2...: 0.007883
Sample size of AE DB......: 1092
Sample size of model......: 932
Missing data %............: 14.65202
- processing Fat10Perc
filter: removed 134 rows (12%), 958 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' S100A9 ' with ' Fat10Perc ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: S100A9
Trait/outcome.............: Fat10Perc
Effect size...............: 0.321517
Standard error............: 0.059535
Odds ratio (effect size)..: 1.379
Lower 95% CI..............: 1.227
Upper 95% CI..............: 1.55
Z-value...................: 5.400502
P-value...................: 6.64546e-08
Hosmer and Lemeshow r^2...: 0.077492
Cox and Snell r^2.........: 0.084188
Nagelkerke's pseudo r^2...: 0.124073
Sample size of AE DB......: 1092
Sample size of model......: 958
Missing data %............: 12.27106
- processing IPH
filter: removed 158 rows (14%), 934 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' S100A9 ' with ' IPH ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: S100A9
Trait/outcome.............: IPH
Effect size...............: 0.056738
Standard error............: 0.048621
Odds ratio (effect size)..: 1.058
Lower 95% CI..............: 0.962
Upper 95% CI..............: 1.164
Z-value...................: 1.166939
P-value...................: 0.2432349
Hosmer and Lemeshow r^2...: 0.0337
Cox and Snell r^2.........: 0.044244
Nagelkerke's pseudo r^2...: 0.059879
Sample size of AE DB......: 1092
Sample size of model......: 934
Missing data %............: 14.46886
- processing MAC_binned
filter: removed 167 rows (15%), 925 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' S100A9 ' with ' MAC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: S100A9
Trait/outcome.............: MAC_binned
Effect size...............: 0.103522
Standard error............: 0.048029
Odds ratio (effect size)..: 1.109
Lower 95% CI..............: 1.009
Upper 95% CI..............: 1.219
Z-value...................: 2.155402
P-value...................: 0.03113038
Hosmer and Lemeshow r^2...: 0.02696
Cox and Snell r^2.........: 0.03631
Nagelkerke's pseudo r^2...: 0.04865
Sample size of AE DB......: 1092
Sample size of model......: 925
Missing data %............: 15.29304
- processing SMC_binned
filter: removed 166 rows (15%), 926 rows remainingfilter_if: no rows removed
Analyzing in dataset ' AERNASE.clin.targets ' the association of ' S100A9 ' with ' SMC_binned ' ...
Collecting data...
We have collected the following and summarize it in an object:
Dataset...................: AERNASE.clin.targets
Score/Exposure/biomarker..: S100A9
Trait/outcome.............: SMC_binned
Effect size...............: -0.132651
Standard error............: 0.049327
Odds ratio (effect size)..: 0.876
Lower 95% CI..............: 0.795
Upper 95% CI..............: 0.965
Z-value...................: -2.689216
P-value...................: 0.007162008
Hosmer and Lemeshow r^2...: 0.025132
Cox and Snell r^2.........: 0.031463
Nagelkerke's pseudo r^2...: 0.043715
Sample size of AE DB......: 1092
Sample size of model......: 926
Missing data %............: 15.20147
cat("Edit the column names...\n")
Edit the column names...
colnames(GLM.results) = c("Dataset", "Predictor", "Trait",
"Beta", "s.e.m.",
"OR", "low95CI", "up95CI",
"Z-value", "P-value", "r^2_l", "r^2_cs", "r^2_nagelkerke", "N", "Model_N", "Perc_Miss")
cat("Correct the variable types...\n")
Correct the variable types...
GLM.results$Beta <- as.numeric(GLM.results$Beta)
GLM.results$s.e.m. <- as.numeric(GLM.results$s.e.m.)
GLM.results$OR <- as.numeric(GLM.results$OR)
GLM.results$low95CI <- as.numeric(GLM.results$low95CI)
GLM.results$up95CI <- as.numeric(GLM.results$up95CI)
GLM.results$`Z-value` <- as.numeric(GLM.results$`Z-value`)
GLM.results$`P-value` <- as.numeric(GLM.results$`P-value`)
GLM.results$`r^2_l` <- as.numeric(GLM.results$`r^2_l`)
GLM.results$`r^2_cs` <- as.numeric(GLM.results$`r^2_cs`)
GLM.results$`r^2_nagelkerke` <- as.numeric(GLM.results$`r^2_nagelkerke`)
GLM.results$`N` <- as.numeric(GLM.results$`N`)
GLM.results$`Model_N` <- as.numeric(GLM.results$`Model_N`)
GLM.results$`Perc_Miss` <- as.numeric(GLM.results$`Perc_Miss`)
# Save the data
cat("Writing results to Excel-file...\n")
Writing results to Excel-file...
### Univariate
write.xlsx(GLM.results,
file = paste0(OUT_loc, "/",Today,".AERNASE.clin.targets.Bin.Uni.",TRAIT_OF_INTEREST,".PlaquePhenotypes.RANK.MODEL1.xlsx"),
rowNames = FALSE, colNames = TRUE, sheetName = "Bin.Uni.PlaquePheno")
# Removing intermediates
cat("Removing intermediate files...\n")
Removing intermediate files...
rm(TRAIT, trait, currentDF, GLM.results, GLM.results.TEMP, fit, model_step)